Document Detail

Spontaneously hypertensive rat neuroanatomy: applications to pharmacological research.
MedLine Citation:
PMID:  21072984     Owner:  NLM     Status:  MEDLINE    
Spontaneously hypertensive rats (SHR), which are normotensive at birth and develop sustained hypertension between 3 and 6 months of age, are the model most extensively investigated for evaluating hypertensive brain damage and its treatment. The time-dependent rise of arterial blood pressure and the occurrence of brain atrophy, loss of nerve cells and glial reaction are shared to some extent with what occurs human hypertensive brain. SHR, therefore, can represent a reasonable model of hypertension-related brain damage. Our main studies on cerebrovascular and brain microanatomical changes occurring in SHR and their sensitivity to pharmacological interventions are summarized.
Francesco Amenta; Seyed Khosrow Tayebati; Daniele Tomassoni
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia     Volume:  115     ISSN:  1122-6714     ISO Abbreviation:  Ital J Anat Embryol     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612303     Medline TA:  Ital J Anat Embryol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  13-7     Citation Subset:  IM    
Anatomia Umana, Università di Camerino, 62032 Camerino.
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MeSH Terms
Brain / blood supply*,  drug effects,  pathology*
Brain Damage, Chronic / drug therapy,  pathology*,  physiopathology*
Disease Models, Animal*
Hypertension / drug therapy,  pathology*,  physiopathology*
Neuropharmacology / methods,  trends
Rats, Inbred SHR / anatomy & histology,  physiology*
Rats, Inbred WKY

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