| Spontaneous tumor lysis syndrome in a child with T-cell acute lymphoblastic leukemia. | |
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MedLine Citation:
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PMID: 19998467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a 5-year-old female who presented with unexplained acute renal failure (ARF) and hyperuricemia and who was subsequently diagnosed of T-cell acute lymphoblastic leukemia (ALL). Peripheral smear was initially unremarkable. She required hemodialysis. Two weeks later, peripheral smear showed 40% blasts and bone marrow demonstrated T-cell ALL. Our case was the fifth and the youngest case of ALL with spontaneous tumor lysis syndrome. However, in contrast to previous reports in ALL or acute myeloid leukemia, our patient did not have blasts noted on periphereal blood smear and her white blood cell count and serum lactate dehydrogenase level were normal on admission, a time when dialysis-dependent ARF and severe hyperuricemia were present. Occult hematologic malignancy should be considered in cases of ARF and hyperuricemia of unknown etiology even when peripheral hematologic findings are not informative. |
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Authors:
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Daisuke Kobayashi; Marcia M Wofford; Thomas W McLean; Jen-Jar Lin |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 54 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-04-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 773-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA. dkobayas@wfubmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Female Humans Hyperuricemia / etiology Kidney Failure, Acute / etiology, therapy Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / complications* Renal Dialysis Tumor Lysis Syndrome / etiology* |
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