Document Detail

Spontaneous transformation of low density lymphocytes as parameter of activity in Hodgkin's disease.
MedLine Citation:
PMID:  7444374     Owner:  NLM     Status:  MEDLINE    
Analysis of spontaneous lymphocyte transformation, as measured by 3H-thymidine incorporation by low density lymphocytes, before and after therapy was performed in 28 patients with Hodgkin's disease. Before treatment increased 3H-thymidine uptake was found in 24 out of 28 patients. Following therapy the spontaneous lymphocyte transformation of the patients in clinical remission returned to the normal range, whereas none of the patients with residual disease achieved these levels. The overall correlation between the uptake of the DNA precursor by low density, lymphocytes and disease activity after treatment was excellent.
B E de Pauw; P H de Mulder; J B Smeulders; D J Wagener; C Haanen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of haematology     Volume:  25     ISSN:  0036-553X     ISO Abbreviation:  Scand J Haematol     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1981-02-24     Completed Date:  1981-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404507     Medline TA:  Scand J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  58-62     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Centrifugation, Density Gradient
DNA / biosynthesis
Drug Therapy, Combination
Follow-Up Studies
Hodgkin Disease / drug therapy,  immunology*,  radiotherapy
Lymphocyte Activation*
Lymphocytes / metabolism
Middle Aged
Reg. No./Substance:

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