Document Detail

Spontaneous superoxide generation by polymorphonuclear leukocytes isolated from patients with stable angina after physical exercise.
MedLine Citation:
PMID:  1334947     Owner:  NLM     Status:  MEDLINE    
The activation of circulating polymorphonuclear leukocytes was determined in terms of O2.- generation and elastase release in patients with stable angina (n = 12) and in control subjects (n = 8) after maximal physical exercise and after a 15-min recovery. There was no spontaneous O2.- formation under basal conditions in both groups of patients. On the contrary, there was significant formation of O2.- (p < 0.001) from patients with stable angina measured directly after exercise, along with a slight spontaneous O2.- formation in control subjects (p < 0.05). After recovery, the spontaneous polymorphonuclear leukocyte-O2.- formation decreased but was still present in the patients with stable angina, while in the healthy subjects these values returned to resting levels. The activation of polymorphonuclear leukocytes with phorbol 12-myristate 13-acetate enhanced O2.- formation both in healthy subjects and in patients with stable angina, with a lesser effect in the latter. Moreover, no differences were observed in polymorphonuclear leukocyte-stimulated O2.- formation during the protocol, both in the angina stable patients and healthy subjects. No changes were found in plasma elastase levels among stable angina patients nor in control subjects as a consequence of exercise or recovery. This study indicates there is an early activation of circulating polymorphonuclear leukocytes in terms of O2.- production in stable angina patients during maximal exercise, which is still present after a 15-min recovery. Such activation occurs without elastase release. However, in healthy subjects maximal exercise resulted in very little increase in neutrophil activation.
C Guarnieri; G Melandri; I Caldarera; V Cervi; F Semprini; A Branzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  37     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-26     Completed Date:  1993-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  301-7     Citation Subset:  IM    
Department of Biochemistry, University of Bologna, Italy.
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MeSH Terms
Angina Pectoris / blood*,  complications,  physiopathology
Evaluation Studies as Topic
Exercise / physiology*
Leukocyte Elastase
Lymphocyte Activation
Middle Aged
Myocardial Ischemia / blood,  etiology,  physiopathology
Neutrophils / physiology*
Pancreatic Elastase / blood*
Superoxides / blood*
Reg. No./Substance:
11062-77-4/Superoxides; EC Elastase; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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