Document Detail

Spontaneous sub-conjunctival haemorrhage in patients using long-term topical corticosteroids.
MedLine Citation:
PMID:  20930855     Owner:  NLM     Status:  MEDLINE    
PURPOSE: to investigate the observed high prevalence of spontaneous sub-conjunctival haemorrhage (SCH) in patients using long-term topical steroid treatment.
PATIENTS AND METHODS: a cross sectional survey of the occurrence of SCH was carried out in 248 patients using steroid eye drops and in a comparison group of 113 patients using topical glaucoma medication.
RESULTS: twenty-four patients with uveitis (10% of total) experienced single or recurrent SCH. Of these 71% used prednisolone acetate 1% (compared with 75% for those unaffected). None of 113 glaucoma patients were affected.
CONCLUSIONS: the long-term use of topical steroid for chronic uveitis substantially increases the prevalence of spontaneous or minimal-trauma SCH. Steroid-induced vascular fragility is the likely cause.
K Mercieca; C Sanghvi; N P Jones
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Publication Detail:
Type:  Journal Article     Date:  2010-10-08
Journal Detail:
Title:  Eye (London, England)     Volume:  24     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-07-27     Revised Date:  2011-08-30    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1770-1     Citation Subset:  IM    
Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, UK.
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MeSH Terms
Adrenal Cortex Hormones / adverse effects*
Conjunctival Diseases / chemically induced*,  epidemiology
Cross-Sectional Studies
Eye Hemorrhage / chemically induced*,  epidemiology
Middle Aged
Ophthalmic Solutions / adverse effects
Uveitis / drug therapy*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Ophthalmic Solutions
Comment In:
Eye (Lond). 2011 Jul;25(7):958-9; author reply 959   [PMID:  21423139 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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