Document Detail


Spontaneous right ventricular thrombus in a patient with active ulcerative colitis and protein C deficiency: a review with a case report.
MedLine Citation:
PMID:  20556925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Inflammatory bowel disease (IBD) is an idiopathic condition of gastrointestinal tract whose pathogenesis results from the complex interaction of genetic susceptibility and environmental influences. Is well known how IBD patients have an increased risk of thrombosis. OBJECTIVES: To assess the frequency and characteristics of thromboembolic events (TEE) in IBD and the role of certain etiopathological factors in such thrombotic patients. MATERIAL AND METHODS: We report the case of a young woman affected by protein C deficiency, who during a clinical recurrence of ulcerative colitis (UC), developed a spontaneous right ventricular thrombus and pulmonary embolism. Then, we made a review of literature that documented thromboembolic events in IBD patients. RESULTS: A search using the PubMed database identified 65 case reports documenting thromboembolic events in patients with known UC and 7 documenting thromboembolic events in known Crohn's disease. DISCUSSION: The data of the literature confirm that IBD patients have an approximately three fold greater risk for developing a TEE compared with the general population. The risk for thrombosis correlates well with disease activity in Crohn's disease, and to lesser extent in ulcerative colitis.
Authors:
R Urgesi; C Zampaletta; A Masini; G Pelecca; A Pastorelli; A De Lorenzo; R Faggiani
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European review for medical and pharmacological sciences     Volume:  14     ISSN:  1128-3602     ISO Abbreviation:  Eur Rev Med Pharmacol Sci     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9717360     Medline TA:  Eur Rev Med Pharmacol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  455-63     Citation Subset:  IM    
Affiliation:
Gastroenterology Unit, BelColle Hospital, Viterbo, Italy. riurgesi@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Colitis, Ulcerative / complications*,  physiopathology
Crohn Disease / complications
Female
Heart Ventricles / pathology
Humans
Protein C Deficiency / complications*
Pulmonary Embolism / etiology
Recurrence
Thrombosis / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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