Document Detail

Spontaneous rhythmic contraction of separated heart muscle cells.
MedLine Citation:
PMID:  5416535     Owner:  NLM     Status:  MEDLINE    
Muscle cells that conitract spontaneously and rhythmically can be obtained from adult mouse myocardium. Contractions are observed immediately after homogenization in a solution that is ionically similar to intracellular fluid. Contraction frequency varies directly with temperature and decreases as a function of time after homogenization. At 16 degrees C rhythmic relaxation and contraction occur for about 20 minutes. Contractions are dependent on the presence of adenosine triphosphate in the homogenization medium.
S Bloom
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  167     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1970 Mar 
Date Detail:
Created Date:  1970-04-14     Completed Date:  1970-04-14     Revised Date:  2011-12-07    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1727-9     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphate / metabolism
Culture Media
Culture Techniques*
Heart / physiology
Heart Ventricles
Muscle Contraction*
Myocardium / cytology*
Reg. No./Substance:
0/Culture Media; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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