Document Detail

Spontaneous resolution of hemophagocytic syndrome associated with acute parvovirus B19 infection and concomitant Epstein-Barr virus reactivation in an otherwise healthy adult.
MedLine Citation:
PMID:  12415473     Owner:  NLM     Status:  MEDLINE    
Reported here is the case of a patient who spontaneously recovered from hemophagocytic syndrome associated with acute B19 infection and concomitant Epstein-Barr virus reactivation. The previously healthy 37-year-old-man was hospitalized after 10 days of high fever, arthralgia and arthritis and was determined to have hemophagocytic syndrome. Immunoglobulin (Ig) M antibodies to Epstein-Barr virus (EBV) capsid antigen, early antigen and parvovirus B19 (B19) were found. B19 DNA and low-level EBV DNA were detected in bone marrow, serum and peripheral blood mononuclear cells. The patient recovered spontaneously without any treatment. Two months later anti-B19 IgG antibodies were detected, while at 9-month follow-up, anti-B19 IgM antibodies were no longer detectable and B19 DNA had disappeared from serum. To the best of our knowledge, this is the first report of spontaneous resolution of hemophagocytic syndrome associated with acute B19 infection and concomitant EBV reactivation in an otherwise healthy adult.
C Larroche; C Scieux; P Honderlick; A M Piette; F Morinet; O Blétry
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2002-09-26
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  21     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-01-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  739-42     Citation Subset:  IM    
Department of Internal Medicine, Hôpital Avicenne, Université Paris-Nord, 125 rue de Stalingrad, 93009 Bobigny, France.
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MeSH Terms
Acute Disease
Epstein-Barr Virus Infections / complications,  diagnosis*,  immunology
Follow-Up Studies
Histiocytosis, Non-Langerhans-Cell / complications,  diagnosis*,  immunology
Parvoviridae Infections / complications,  diagnosis*,  immunology
Parvovirus B19, Human / isolation & purification*
Remission, Spontaneous

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