| Spontaneous resolution of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. | |
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MedLine Citation:
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PMID: 20806367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secondary hemophagocytic lymphohistiocytosis (sHLH) is a reactive, proliferative disorder of the immune system resulting in lymphohistiocytic proliferation, hemophagocytosis, and cytokine dysregulation. The most common infectious trigger in sHLH is Epstein-Barr virus (EBV-HLH). Current treatment protocols for EBV-HLH have a cure rate of approximately 75%; however, there are significant toxicities associated with these therapies. We present two patients with EBV-HLH who experienced spontaneous resolution of their disease prior to the initiation of therapy, suggesting there may be a subgroup of patients with EBV-HLH who do well with conservative management and can avoid potentially toxic therapies. |
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Authors:
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Brian Belyea; Ashley Hinson; Cassandra Moran; Eugene Hwang; Jessica Heath; Raymond Barfield |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 55 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 754-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Wiley-Liss, Inc. |
Affiliation:
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Division of Pediatric Hematology and Oncology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA. brian.belyea@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Epstein-Barr Virus Infections / complications* Female Humans Lymphohistiocytosis, Hemophagocytic / diagnosis* Male |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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