Document Detail

Spontaneous renal tubular carcinoma in Fischer-344 rat littermates.
MedLine Citation:
PMID:  7483218     Owner:  NLM     Status:  MEDLINE    
Two of 632 Fischer-344 rats in a food restriction study had spontaneous, bilateral, multicentric renal tubular cell carcinomas. Although there were 104 litters represented in this study, both rats that developed this rare neoplasm were from the same litter. The littermates, one male and one female, were in the food-restricted treatment groups (60% of ad libitum intake) and were 550 and 447 days old, respectively, at death. The probability that the two rare bilateral renal neoplasms occurred by a chance event in littermates is approximately 0.8%. The apparent familial predisposition for development of specific types of neoplasms emphasizes the importance of randomization of individuals into treatment groups and consideration of lineage for rare tumors.
J D Thurman; J R Hailey; A Turturro; D W Gaylor
Related Documents :
6955798 - Action of food restriction in delaying the aging process.
7666248 - Food restriction inhibits an autoimmune disease resembling systemic lupus erythematosus...
25411298 - Research issues: the food environment and obesity.
496738 - Effects of caecectomy in the young adult female rat on digestibility of food offered ad...
11978628 - Effects of acute and chronic administration of the melanocortin agonist mtii in mice wi...
19894148 - Screening for tetracycline residues in food products of animal origin in the state of k...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Veterinary pathology     Volume:  32     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-30     Completed Date:  1995-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  419-22     Citation Subset:  IM    
Springborn Laboratories, Spencerville, OH 45887, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carcinoma, Renal Cell / genetics,  pathology,  veterinary*
Kidney Neoplasms / genetics,  pathology,  veterinary*
Rats, Inbred F344*
Rodent Diseases / epidemiology,  genetics*,  pathology
Specific Pathogen-Free Organisms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biliary cystadenoma of cats.
Next Document:  Primary gastrointestinal lymphosarcoma with epitheliotropism in three Shar-pei and one boxer dog.