Document Detail

Spontaneous renal tubular carcinoma in Fischer-344 rat littermates.
MedLine Citation:
PMID:  7483218     Owner:  NLM     Status:  MEDLINE    
Two of 632 Fischer-344 rats in a food restriction study had spontaneous, bilateral, multicentric renal tubular cell carcinomas. Although there were 104 litters represented in this study, both rats that developed this rare neoplasm were from the same litter. The littermates, one male and one female, were in the food-restricted treatment groups (60% of ad libitum intake) and were 550 and 447 days old, respectively, at death. The probability that the two rare bilateral renal neoplasms occurred by a chance event in littermates is approximately 0.8%. The apparent familial predisposition for development of specific types of neoplasms emphasizes the importance of randomization of individuals into treatment groups and consideration of lineage for rare tumors.
J D Thurman; J R Hailey; A Turturro; D W Gaylor
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Veterinary pathology     Volume:  32     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-30     Completed Date:  1995-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  419-22     Citation Subset:  IM    
Springborn Laboratories, Spencerville, OH 45887, USA.
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MeSH Terms
Carcinoma, Renal Cell / genetics,  pathology,  veterinary*
Kidney Neoplasms / genetics,  pathology,  veterinary*
Rats, Inbred F344*
Rodent Diseases / epidemiology,  genetics*,  pathology
Specific Pathogen-Free Organisms

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