Document Detail

Spontaneous remission of primary hyperparathyroidism: a case report and meta-analysis of the literature.
MedLine Citation:
PMID:  16284975     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In a minority of patients, primary hyperparathyroidism spontaneously remits either by autoinfarction or by hemorrhage into or around the adenoma. We describe a case of autoparathyroidectomy occurring in a 63-year-old man 9 years after three parathyroid glands were removed during a total thyroidectomy. This case is compared with 50 previously reported cases of autoparathyriodectomy, and a meta-analysis is performed. METHODS: Case report, literature review, and meta-analysis were done using statistical software (SigmaStat 2.0, SPSS, Chicago). RESULTS: Fifty cases of autoparathyroidectomy were summarized according to the three etiologies. The greatest biochemical aberration was found in the acute intracapsular hemorrhage group, with [Ca(++)] falling from a mean 15.1 mg/dL to 8.9 mg/dL. The average drop in parathyroid hormone was 69% across all groups, comparing favorably to surgical resection. CONCLUSIONS: Autoparathyroidectomy is a rare but described outcome of unoperated primary hyperparathyroidism that may delay or supplant operative management.
Christopher T Wootten; Eric A Orzeck
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Publication Detail:
Type:  Case Reports; Journal Article; Meta-Analysis; Review    
Journal Detail:
Title:  Head & neck     Volume:  28     ISSN:  1043-3074     ISO Abbreviation:  Head Neck     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-21     Completed Date:  2006-07-06     Revised Date:  2006-10-05    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Copyright Information:
(c) 2005 Wiley Periodicals, Inc. Head Neck 27: XXX-XXX, 2005.
Department of Otolaryngology, Vanderbilt University, 1215 21st Avenue South, Nashville, Tennessee 37232, USA.
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MeSH Terms
Adenoma / complications*,  physiopathology,  radionuclide imaging
Hyperparathyroidism, Primary / etiology,  physiopathology*,  radionuclide imaging
Middle Aged
Parathyroid Neoplasms / complications*,  physiopathology,  radionuclide imaging
Remission, Spontaneous

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