| Spontaneous remission of infantile spasms and hypsarrhythmia following acute infection with high-grade fever. | |
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MedLine Citation:
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PMID: 17964758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To elucidate the pathogenesis of spontaneous remission of infantile spasms (ISs) and hypsarrhythmia following infection, we reviewed 58 patients with ISs from 1986 through 2006 in our hospital. Five patients showed spontaneous remission of spasms or hypsarrhythmia following infections with high-grade fever (SR group). In control, we analyzed five patients with complete improvement of ISs for ACTH therapy (ACTH group). In the SR group, ISs stopped in an average of 4.0 days after the onset of infection. In three patients performing EEG during the infection, hypsarrhythmia disappeared within an average of 8 days after the onset of infection. In the ACTH group, ISs stopped an average of 4.6 days and hypsarrhythmia disappeared within an average of 10 days after ACTH therapy. During the remission course of ISs, low-voltage background activity (BGA) on EEG showed in one patient of the SR group and in all patients of the ACTH group. ACTH is known to the efficacy for ISs and suppression of cortical activity on human EEG. This similar remission course between in the SR group and in the ACTH group suggest neuroendocrinal products in response to infection, which is resembled ACTH-related cascade, may play a role for spontaneous remission following infection. |
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Authors:
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Chitose Sugiura; Yoshihiro Maegaki; Hiroko Kure; Takehiko Inoue; Kousaku Ohno |
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Publication Detail:
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Type: Journal Article Date: 2007-10-26 |
Journal Detail:
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Title: Epilepsy research Volume: 77 ISSN: 0920-1211 ISO Abbreviation: Epilepsy Res. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-26 Completed Date: 2008-02-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 102-7 Citation Subset: IM |
Affiliation:
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Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36-1 Nishimachi, Yonago 683-8504, Japan. sugiurac@grape.med.tottori-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenocorticotropic Hormone / therapeutic use Child Child, Preschool Databases, Factual Electroencephalography Female Fever / epidemiology, physiopathology* Humans Infant Infection / epidemiology, physiopathology* Male Remission, Spontaneous Retrospective Studies Spasms, Infantile / drug therapy, epidemiology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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