Document Detail

Spontaneous remission of functioning pituitary adenomas without hypopituitarism following infarctive apoplexy: two case reports.
MedLine Citation:
PMID:  15758567     Owner:  NLM     Status:  MEDLINE    
Functioning pituitary adenomas may exhibit spontaneous remission after pituitary apoplexy usually in association with hypopituitarism. We report two patients who presented with sudden headache and double vision, showed a ring-enhanced sellar tumor on MRI, underwent transsphenoidal surgery that revealed a coagulation necrotic adenoma without massive hemorrhage, and showed normal pituitary function after the surgery. Definitive diagnoses were made based on immunohistochemistry of the necrotic cells. The findings were consistent with the presence of selective infarct of a GH adenoma and a prolactinoma that had led to remission of acromegaly and menstrual disturbance, respectively, without pituitary insufficiency. In contrast to hemorrhagic apoplexy, infarctive apoplexy tends to affect only the tumor and thus presents with mild symptoms and lack pituitary deficiencies.
Hiroshi Nishioka; Jo Haraoka; Tamotsu Miki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Endocrine journal     Volume:  52     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-10     Completed Date:  2005-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  117-23     Citation Subset:  IM    
Department of Neurosurgery, Tokyo Medical University, Tokyo, Japan.
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MeSH Terms
Acromegaly / etiology
Adenoma / blood supply*,  complications,  diagnosis,  surgery
Human Growth Hormone / secretion
Infarction / physiopathology*
Magnetic Resonance Imaging
Middle Aged
Pituitary Apoplexy / physiopathology*
Pituitary Neoplasms / blood supply*,  complications,  diagnosis,  surgery
Postoperative Period
Prolactinoma / blood supply,  physiopathology
Remission, Spontaneous
Reg. No./Substance:
12629-01-5/Human Growth Hormone

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