| Spontaneous remission of ectopic Cushing's syndrome due to pheochromocytoma: a case report. | |
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MedLine Citation:
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PMID: 8921826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A young female adult with Cushing's syndrome arising from ectopic production of corticotropin (ACTH) from an adrenal pheochromocytoma showed spontaneous clinical and biochemical remission of hypercortisolism after a brief period of ketoconazole administration. Despite continued remission of the hypercortisolism over the next 18 months, there was progressive catecholamine hypersecretion with significant morbidity as a result of the pheochromocytoma. Surgical resection of the left adrenal gland revealed a pheochromocytoma showing focal cytoplasmic immunostaining for ACTH and marked diffuse compact cell hyperplasia in the adrenocortical tissue. To our knowledge this is the first reported case of spontaneous clinical and biochemical remission of ectopic ACTH production from a pheochromocytoma. The pathogenesis of the remission remains unknown. |
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Authors:
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K C Loh; R Gupta; A H Shlossberg |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 135 ISSN: 0804-4643 ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-12-30 Completed Date: 1996-12-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 440-3 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Dalhousie University, Halifax, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ACTH Syndrome, Ectopic
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etiology* Adrenal Gland Neoplasms / complications*, pathology, radiography Adult Cushing Syndrome / etiology*, physiopathology* Female Humans Pheochromocytoma / complications*, pathology, radiography Remission, Spontaneous Tomography, X-Ray Computed |
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