| Spontaneous remission of acute leukemia after the termination of pregnancy. | |
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MedLine Citation:
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PMID: 2647279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 28-year-old woman in the third trimester of her pregnancy was found to have acute myelocytic leukemia. The baby was delivered by Cesarean section and her leukemia underwent spontaneous remission. However, 3 months later, she presented with massive painful leukemic infiltration of the breasts as initial manifestation of relapse, followed by systemic symptoms of leukemia. In vitro culture of the leukemic cells demonstrated characteristics of macrophage cell line. This case illustrates a unique sequence of events: spontaneous remission after the termination of pregnancy, which has profound hormonal alterations, and relapse in a very hormone-sensitive organ, the breast, a few months later when the hormonal milieu was resumed. This suggests hormonal dependence of her leukemic cells and potential for hormonal manipulation in a certain subset of human leukemia. |
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Authors:
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J Antunez de Mayolo; Y S Ahn; J D Temple; W J Harrington |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cancer Volume: 63 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-05-05 Completed Date: 1989-05-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1621-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Miami Veteran's Administration Hospital, Florida. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Leukemia, Myeloid, Acute / physiopathology* Pregnancy Pregnancy Complications, Neoplastic / physiopathology* Recurrence Remission, Spontaneous |
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