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Spontaneous regression of transplacental metastases from maternal melanoma in a newborn: case report and review of the literature.
MedLine Citation:
PMID:  20948450     Owner:  NLM     Status:  In-Process    
We describe a rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman. She was aware of a greyish-brown nodular lesion on the right gluteus during her first pregnancy. On histological examination, this lesion resulted to be an amelanocitic melanoma. Breast metastases occurred during her second pregnancy, 18 months after the surgical excision; an emergency Caesarean section performed for the recrudement of her clinical conditions confirmed widespread metastases to the liver, spleen and peritoneum. The patient died 2 weeks after delivery. The newborn, at 3 months of age, presented metastases secondary to maternal melanoma, which were resistant to chemotherapy. The disease regressed spontaneously and the child is now 24 months, alive in complete remission.
Mario Valenzano Menada; Melita Moioli; Alberto Garaventa; Paolo Nozza; Marilena Foppiano; Nadia Trimarchi; Ezio Fulcheri
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Melanoma research     Volume:  20     ISSN:  1473-5636     ISO Abbreviation:  Melanoma Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109623     Medline TA:  Melanoma Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  443-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, San Martino Hospital, University of Genoa, Italy.
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