Document Detail

Spontaneous regression of metastases from melanoma: review of the literature.
MedLine Citation:
PMID:  19633580     Owner:  NLM     Status:  MEDLINE    
Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unknown, some event must trigger the immune system to produce a stronger than normal response that results in regression of the melanoma metastases. Immunologic studies of patients with regression may disclose the underlying mechanisms and lead to new therapies of disseminated melanoma.
Louise Vennegaard Kalialis; Krzysztof T Drzewiecki; Helle Klyver
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Melanoma research     Volume:  19     ISSN:  1473-5636     ISO Abbreviation:  Melanoma Res.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-10     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109623     Medline TA:  Melanoma Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-82     Citation Subset:  IM    
Department of Plastic Surgery and Burn Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Lymphatic Metastasis
Melanoma / immunology*,  pathology,  secondary*
Neoplasm Regression, Spontaneous / immunology*
Skin Neoplasms / immunology*,  pathology,  secondary*

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