Document Detail

Spontaneous recovery from nondepolarizing neuromuscular blockade: correlation between clinical and evoked responses.
MedLine Citation:
PMID:  138369     Owner:  NLM     Status:  MEDLINE    
The effects of nondepolarizing muscle relaxants were allowed to wear off spontaneously in 10 ASA class III and IV patients following major surgery. Neuromuscular and respiratory function were followed by clinical testing and by evoked muscle responses using a train of 4 (TOF) supramaximal stimuli. At a TOF of 70 percent (range 62 to 78%), all patients sustained eye-opening, hand-grasp, and tongue-protrusion, while 9/10 sustained head-lift. Vital capacity (VC) averaged 17 ml/kg when the TOF reached 70 percent. The increase in VC correlated with the increase in TOF (r = 0.88). There was no correlation between inspiratory force (IF) and TOF, but all patients achieved an IF equal to or greater than -22 cm H2O at 70 percent. Thus, TOF correlates well with clinical signs of neuromuscular and respiratory recovery in this group of patients and complements earlier studies in healthy anesthetized patients and nonmedicated volunteers.
J B Brand; D J Cullen; N E Wilson; H H Ali
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  56     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:    1977 Jan-Feb
Date Detail:
Created Date:  1977-03-31     Completed Date:  1977-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-8     Citation Subset:  IM    
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MeSH Terms
Electric Stimulation
Neuromuscular Junction / drug effects*
Neuromuscular Nondepolarizing Agents / pharmacology*
Pancuronium / pharmacology
Reflex / drug effects
Respiration / drug effects
Succinylcholine / pharmacology
Time Factors
Tubocurarine / pharmacology
Vital Capacity / drug effects
Reg. No./Substance:
0/Neuromuscular Nondepolarizing Agents; 0/Pancuronium; 306-40-1/Succinylcholine; 57-95-4/Tubocurarine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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