Document Detail

Spontaneous recovery of diaphragmatic strength in unilateral diaphragmatic paralysis.
MedLine Citation:
PMID:  16618539     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to evaluate diaphragmatic strength in patients with unilateral diaphragmatic paralysis and to determine whether patients with recent diaphragm paralysis develop lower inspiratory pressure than patients with longstanding diaphragmatic paralysis. Twenty patients (16 men and 4 women, 62+/-12 years) and six control subjects were included (4 men and 2 women, 53+/-15 years) in the study. Esophageal pressure during sharp sniff (Pes,sniff), bilateral cervical phrenic nerve magnetic stimulation (Pes,cms) and unilateral phrenic nerve stimulation (Pes,ums) (in nine patients) were measured. Sixteen patients presented right diaphragmatic paralysis and four, left diaphragmatic paralysis. Pes,sniff was higher in control subjects than in patients with diaphragmatic paralysis (respectively 110+/-22 cmH2O and 82+/-24 cmH2O, P<0.05). There was no difference in Pes,cms between patients with diaphragmatic paralysis and control subjects (14+/-7 cmH2O vs. 16+/-4 cmH2O; ns). Pes,ums after stimulation of the affected phrenic nerve was less than 4 cmH2O, was 8+/-2 cmH2O after stimulation of the intact phrenic nerve and was correlated to Pes,cms (R=0.87, P<0.01). There was a positive correlation between Pes,cms, Pes,ums of the intact hemidiaphragm, Pes,sniff and the time from the onset of symptoms and the diaphragmatic explorations (respectively R=0.86, P<0.0001; R=0.72, P<0.05; R=0.48, P<0.05). In conclusion, diaphragmatic strength after unilateral diaphragmatic paralysis seems to improve with time.
Eric Verin; Jean-Paul Marie; Catherine Tardif; Philippe Denis
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Publication Detail:
Type:  Journal Article     Date:  2006-04-18
Journal Detail:
Title:  Respiratory medicine     Volume:  100     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-10     Completed Date:  2007-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1944-51     Citation Subset:  IM    
Service de Physiologie digestive, urinaire, respiratoire et sportive, CHU de ROUEN-1 rue de Germont, 76031 ROUEN Cedex, France.
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MeSH Terms
Aged, 80 and over
Breath Tests
Diaphragm / physiopathology*
Electric Stimulation / methods
Electromyography / methods
Esophagus / physiology
Middle Aged
Muscle Strength / physiology*
Phrenic Nerve / physiology
Recovery of Function
Respiratory Function Tests
Respiratory Paralysis / diagnosis,  physiopathology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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