Document Detail


Spontaneous recovery of dermatomyositis and unspecified myositis in three adult patients.
MedLine Citation:
PMID:  18487558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dermatomyositis (DM), polymyositis and unspecified myositis are idiopathic inflammatory myopathies in which prednisone is usually started as soon as the diagnosis has been established. Therefore, little is known about the natural history of these diseases and spontaneous recovery may escape attention. Here, we present three patients who achieved remission without administration of immunosuppressants. In these three patients, treatment was not started because of spontaneously improving symptoms and signs during the diagnostic process. After 3-5 years, all patients are still free of muscle weakness. These case reports demonstrate that spontaneous long lasting remission can occur in a small proportion of patients with subacute onset idiopathic inflammatory myopathies. In some patients, immunosuppressive treatment with the risk of serious side effects can perhaps be omitted. However, close and frequent monitoring is required in these instances.
Authors:
J van de Vlekkert; J E Hoogendijk; C J M Frijns; M de Visser
Related Documents :
10616048 - Association between alopecia and response to aggressive chemotherapy in patients with h...
25298618 - The antioxidant profiles, lysosomal and membrane enzymes activity in patients with acut...
2573388 - Sensitivity to both vecuronium and neostigmine in a sero-negative myasthenic patient.
10812498 - Features of polymyositis and dermatomyositis in the elderly: a case-control study.
12571838 - Eligibility of patients in routine care for major clinical trials of anti-tumor necrosi...
22898628 - Demystifying seronegative autoimmune pancreatitis.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  79     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  729-30     Citation Subset:  IM    
Affiliation:
Academic Medical Centre, Department of Neurology, University of Amsterdam, Amsterdam, The Netherlands. j.vandevlekkert@amc.uva.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / etiology
Adult
Aged
Biopsy
Carcinoma, Non-Small-Cell Lung / diagnosis,  pathology
Creatine Kinase / blood
Dermatomyositis / diagnosis*,  pathology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Muscle, Skeletal / pathology
Myositis / diagnosis*,  pathology
Neoplasm Staging
Neurologic Examination
Paraneoplastic Syndromes / diagnosis,  pathology
Pregnancy
Pregnancy Complications / diagnosis,  pathology
Remission, Spontaneous
Chemical
Reg. No./Substance:
EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genes involved in the transforming growth factor beta signalling pathway and the risk of intracrania...
Next Document:  Randomized phase II trial of induction chemotherapy followed by concurrent chemotherapy and dose-esc...