Document Detail

Spontaneous pulmonary squamous cell carcinoma in an aging CD rat.
MedLine Citation:
PMID:  8801717     Owner:  NLM     Status:  MEDLINE    
Naturally occurring squamous cell carcinomas of lung of laboratory rodents are rare, and few cases have been reported and illustrated. A solid peripheral lung mass was observed grossly in a untreated 573-day-old male Sprague Dawley CD (Crl:CD [SD] BR) rat. Microscopically, the mass was composed of neoplastic squamous epithelial cells arranged in nests, cords, nodules, or solid sheets. Epithelial pearls were present. The mitotic index was high, and intercellular bridging (prickles) was noted. In some areas, neoplastic cells rimmed large cystic areas containing neutrophils, cell debris, and laminated keratin masses. Neoplastic cells had both expansive and invasive growth with entrapment of bronchioles and marked fibroplasia.
H C Chen; C T Liang; C C Hong; Y J Huang; I J Pan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  33     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-10-01     Completed Date:  1996-10-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  228-30     Citation Subset:  IM    
National Laboratory Animal Breeding and Research Center, National Science Council, Taipei, Taiwan (ROC).
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MeSH Terms
Age Factors
Carcinoma, Squamous Cell / pathology,  veterinary*
Lung Neoplasms / pathology,  veterinary*
Rats, Sprague-Dawley*

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