Document Detail

Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion.
MedLine Citation:
PMID:  21187445     Owner:  NLM     Status:  In-Data-Review    
Abnormal maternal inflammation during pregnancy is associated with spontaneous pregnancy loss and intrauterine fetal growth restriction. However, the mechanisms responsible for these pregnancy outcomes are not well understood. In this study, we used a rat model to demonstrate that pregnancy loss resulting from aberrant maternal inflammation is closely linked to deficient placental perfusion. Administration of LPS to pregnant Wistar rats on gestational day 14.5, to induce maternal inflammation, caused fetal loss in a dose-dependent manner 3-4 h later, and surviving fetuses were significantly growth restricted. Pregnancy loss was associated with coagulopathy, structural abnormalities in the uteroplacental vasculature, decreased placental blood flow, and placental and fetal hypoxia within 3 h of LPS administration. This impairment in uteroplacental hemodynamics in LPS-treated rats was linked to increased uterine artery resistance and reduced spiral arteriole flow velocity. Pregnancy loss induced by LPS was prevented by maternal administration of the immunoregulatory cytokine IL-10 or by blocking TNF-α activity after treatment with etanercept (Enbrel). These results indicate that alterations in placental perfusion are responsible for fetal morbidities associated with aberrant maternal inflammation and support a rationale for investigating a potential use of immunomodulatory agents in the prevention of spontaneous pregnancy loss.
Stephen J Renaud; Tiziana Cotechini; Jill S Quirt; Shannyn K Macdonald-Goodfellow; Maha Othman; Charles H Graham
Related Documents :
21352635 - The fetal safety of hydrocortisone-pramoxine (proctofoam-hc) for the treatment of hemor...
23893675 - Perinatal complications and higher risks of offspring thyroid dysfunction in early chil...
21371805 - Post-abortion-hysteroscopy: a method for early diagnosis of congenital and acquired int...
21366395 - The effect of maternal obesity on pregnancy outcomes in women with gestational diabetes.
8550905 - Growth and accretion of energy and protein in the gravid uterus during late pregnancy i...
16284065 - Recruitment of sperm donors: the newcastle-upon-tyne experience 1994-2003.
Publication Detail:
Type:  Journal Article     Date:  2010-12-27
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  186     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1799-808     Citation Subset:  AIM; IM    
Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada K7L3N6.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Langerin+ Dermal Dendritic Cells Are Critical for CD8+ T Cell Activation and IgH {gamma}-1 Class Swi...
Next Document:  TNF Receptor-1 Is Required for the Formation of Splenic Compartments during Adult, but Not Embryonic...