Document Detail

Spontaneous pregnancy after a pregnancy induced by treatment in hyperprolactinemic women.
MedLine Citation:
PMID:  2335246     Owner:  NLM     Status:  MEDLINE    
The relationship between spontaneous pregnancy of hyperprolactinemic patients after a first pregnancy induced by treatment and their serum prolactin levels was examined. Of the 100 patients with hyperprolactinemia studied, 74 became pregnant after treatment; namely, 20 transsphenoidal adenomoidectomy for pituitary prolactinoma (group 1), 26 on treatment with bromocriptine for pituitary prolactinoma (group 2), and 28 on treatment with bromocriptine for hyperprolactinemia without prolactinoma (group 3). After delivery in the first pregnancy, the rates of menstrual restoration and subsequent spontaneous pregnancy in group 1 (72.2% and 75.0%) were significantly (p less than 0.05) higher than those in group 2 (32.0% and 25%) and group 3 (13.6% and 18.2%). The serum levels of prolactin after the first pregnancy and weaning were significantly (p less than 0.05) lower in patients with subsequent spontaneous pregnancy than in patients without spontaneous pregnancy in each group, and the levels in patients with spontaneous pregnancy were significantly (p less than 0.05) lower in group 1 (15.2 +/- 8.8 ng/ml) than in group 2 (46.6 +/- 2.9 ng/ml). These data suggest that the transsphenoidal adenomoidectomy for pituitary prolactinoma may be better than bromocriptine treatment for recovery of reproductive function.
M Yamada; A Miyake; K Koike; H Ikegami; T Aono; O Tanizawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  35     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:    1990 May-Jun
Date Detail:
Created Date:  1990-06-13     Completed Date:  1990-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
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MeSH Terms
Bromocriptine / pharmacology
Hyperprolactinemia / therapy*
Infertility, Female / therapy*
Pituitary Neoplasms / surgery*
Prolactin / blood
Prolactinoma / surgery*
Reg. No./Substance:
25614-03-3/Bromocriptine; 9002-62-4/Prolactin

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