Document Detail

Spontaneous phasic activity of isolated human coronary arteries.
MedLine Citation:
PMID:  6783306     Owner:  NLM     Status:  MEDLINE    
The functional behaviour and pharmacological responses of ring segments of large coronary arteries removed from five patients undergoing cardiac transplantation were studied in vitro. All segments showed spontaneous rhythmic contractions which were markedly dependent on external calcium and were rapidly abolished in calcium-free solutions and by verapamil. The contractions were inhibited by cooling and by anoxia. Phasic activity was enhanced by increasing the external potassium concentration over the range 5 to 20 mmol.litre-1 but was abolished by 120 mmol.litre-1 potassium. Noradrenaline and ergonovine enhanced or induced phasic activity. The behaviour of human coronary arteries resembles that of the portal-mesenteric veins of many species and our results suggest that the activation mechanisms of these two tissues may be similar.
G Ross; E Stinson; J Schroeder; R Ginsburg
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  14     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  613-8     Citation Subset:  IM    
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MeSH Terms
Calcium / pharmacology
Coronary Vessels / physiology*
Ergonovine / pharmacology
Muscle Contraction* / drug effects
Muscle, Smooth, Vascular / physiology
Nitroglycerin / pharmacology
Norepinephrine / pharmacology
Oxygen / pharmacology
Potassium / pharmacology
Reg. No./Substance:
51-41-2/Norepinephrine; 55-63-0/Nitroglycerin; 60-79-7/Ergonovine; 7440-09-7/Potassium; 7440-70-2/Calcium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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