Document Detail


Spontaneous persistent activity in entorhinal cortex modulates cortico-hippocampal interaction in vivo.
MedLine Citation:
PMID:  23042081     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal cortex layer III (MECIII) neurons, a gateway between neocortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo, implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
Authors:
Thomas T G Hahn; James M McFarland; Sven Berberich; Bert Sakmann; Mayank R Mehta
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-07
Journal Detail:
Title:  Nature neuroscience     Volume:  15     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-01-03     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1531-8     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biophysics
Electric Stimulation
Entorhinal Cortex / physiology*
Hippocampus / physiology*
Markov Chains
Membrane Potentials / physiology*
Mice
Mice, Inbred C57BL
Neocortex / physiology*
Neural Pathways / physiology
Neurons / physiology*
Statistics, Nonparametric
Stochastic Processes
Grant Support
ID/Acronym/Agency:
5R01MH092925-02/MH/NIMH NIH HHS; R01 MH092925/MH/NIMH NIH HHS
Comments/Corrections
Comment In:
Nat Neurosci. 2012 Nov;15(11):1471-2   [PMID:  23103991 ]

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