Document Detail


Spontaneous pericardial hematoma with familial amyloid polyneuropathy.
MedLine Citation:
PMID:  19922334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are more than a few risks of hemorrhage complication in patients with amyloidosis. Although most cases with amyloidosis exhibit minor bleeding manifestations, they can be occasionally associated with life-threatening problems. To our knowledge, there are only a few cases of spontaneous pericardial hematoma associated with amyloidosis. We here report a patient who suddenly died of cardiac tamponade with massive pericardial hematoma 7 years after the diagnosis of familial amyloid polyneuropathy (FAP). A 69-year-old female with FAP with cardiogenic shock was admitted to our emergency room. Although she previously underwent permanent pacemaker implantation for atrial fibrillation with slow ventricular response, electrocardiogram showed a critical pacing failure. Emergent telemetry check revealed a sudden extreme increase of pacing capture threshold in the right ventricle. Maximum pacing voltage could not improve the critical condition, and she died 7 h after arrival. Autopsy showed a massive pericardial hematoma in the right ventricular free wall, and microscopic examination revealed typical amyloid deposition in the arterial wall of the pericardium. In this case, it is assumed that a sudden rupture of fragile pericardial vessels with amyloid deposition led to the lethal pericardial hematoma.
Authors:
Naohiko Nakanishi; Takahisa Sawada; Rena Sato; Kenji Yanishi; Yoshiki Akakabe; Shinya Nishizawa; Akira Kuroyanagi; Yoshinori Tsubakimoto; Akihiro Matsui; Takeshi Nakamura; Hirokazu Shiraishi; Akiyoshi Matsumuro; Takeshi Shirayama; Hiroaki Matsubara
Related Documents :
9033354 - Antimyosin antibodies in cardiac rejection.
24911984 - Hypertrabeculation vs left ventricular noncompaction on echocardiogram: a reason to res...
11581134 - Infusion of light chains from patients with cardiac amyloidosis causes diastolic dysfun...
10779154 - New animal model of diphtheritic myocarditis.
11233554 - Enhanced 99tc(m)-mibi spect detection of hibernating myocardium following the use of su...
19149884 - Electrocardiographic (ecg) criteria for determining left ventricular mass in young heal...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis     Volume:  16     ISSN:  1744-2818     ISO Abbreviation:  Amyloid     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433802     Medline TA:  Amyloid     Country:  England    
Other Details:
Languages:  eng     Pagination:  221-5     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan. naka-nao@koto.kpu-m.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Amyloid Neuropathies, Familial / complications*,  physiopathology*
Fatal Outcome
Female
Hematoma / diagnosis,  etiology*
Humans
Pericardium / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Isolation and characterization of monoclonal antibodies against bovine serum amyloid A1 protein.
Next Document:  Amyloid arthropathy mimicking seronegative rheumatoid arthritis in multiple myeloma: case reports an...