Document Detail


Spontaneous pathology of the baboon endocrine system.
MedLine Citation:
PMID:  19793179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Study of endocrine pathology in animal models is critical to understanding endocrine pathology in humans.
METHODS: We evaluated 434 endocrine-related diagnoses from 4619 baboon necropsies, established the incidence of spontaneous endocrine pathology, and analyzed the clinical and biochemical data associated with the individual cases.
RESULTS: The most common diagnoses in descending order, were pancreatic islet cell amyloidosis (n = 259), ovarian cysts (n = 50), pituitary adenoma (n = 37), pancreatic islet cell adenoma (n = 20), granulosa cell tumor (n = 15), thyroid adenoma (n = 11), adrenal hyperplasia (n = 10), thyroid carcinoma (n = 8), and pheochromocytoma (n = 6). The incidence of pancreatic islet cell amyloidosis progressively increased with age. Pheochromocytomas were associated with renal and heart failure. The incidence of pancreatic islet cell amyloidosis and adrenal pathology was similar to humans; the incidence of pituitary adenoma and thyroid pathology was lower than in humans.
CONCLUSIONS: Endocrine disease in baboons is common and shares clinical and biochemical characteristics with endocrine disease in humans.
Authors:
R Guardado-Mendoza; E J Dick; L M Jimenez-Ceja; A Davalli; A O Chavez; F Folli; G B Hubbard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-09-28
Journal Detail:
Title:  Journal of medical primatology     Volume:  38     ISSN:  1600-0684     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2010-01-14     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  383-9     Citation Subset:  IM    
Affiliation:
Diabetes Division, University of Texas Health Science Center, San Antonio, TX, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Comorbidity
Endocrine System Diseases / epidemiology,  veterinary*
Female
Humans
Incidence
Male
Monkey Diseases / epidemiology*
Papio*
Grant Support
ID/Acronym/Agency:
C06 RR016228/RR/NCRR NIH HHS; P51 RR013986/RR/NCRR NIH HHS; P51 RR013986-11/RR/NCRR NIH HHS
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