Document Detail


Spontaneous onset of atrial fibrillation.
MedLine Citation:
PMID:  20160895     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Most commonly, atrial fibrillation is triggered by rapid bursts of electrical impulses originating in the myocardial sleeves of pulmonary veins (PVs). However, the nature of such bursts remains poorly understood. Here, we propose a mechanism of bursting consistent with the extensive empirical information about the electrophysiology of the PVs. The mechanism is essentially non-local and involves the spontaneous initiation of non-sustained spiral waves in the distal end of the muscle sleeves of the PVs. It reproduces the experimentally observed dynamics of the bursts, including their frequency, their intermittent character, and the unusual shape of the electrical signals in the pulmonary veins that are reminiscent of so-called early afterdepolarizations (EADs).
Authors:
Christian W Zemlin; Bogdan G Mitrea; Arkady M Pertsov
Related Documents :
15072975 - Effects of procainamide on electrical activity in thoracic veins and atria in canine mo...
15633445 - Periodic conduction and 2:1 block from the left atrium to the pulmonary vein during rad...
20103375 - A multidisciplinary approach to the minimally invasive pulmonary vein isolation for tre...
7513865 - Coincident idiopathic left ventricular tachycardia and atrioventricular nodal reentrant...
17520435 - Endovascular coiling of intracranial aneurysms using bioactive coils: a single-center s...
21698515 - Cytokine balance in hepatosplanchnic system during thoracoabdominal aortic aneurysm rep...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Physica D. Nonlinear phenomena     Volume:  238     ISSN:  0167-2789     ISO Abbreviation:  -     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2010-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9890573     Medline TA:  Physica D     Country:  -    
Other Details:
Languages:  ENG     Pagination:  969-975     Citation Subset:  -    
Affiliation:
Department of Pharmacology, SUNY Upstate Medical University, Syracuse, New York 13210, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 HL071762-05A2//NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An Efficient, Microwave-Assisted, One-Pot Synthesis of Indoles Under Sonogashira Conditions.
Next Document:  Winter Depression: Integrating mood, circadian rhythms, and the sleep/wake and light/dark cycles int...