| Spontaneous onset of atrial fibrillation. | |
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MedLine Citation:
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PMID: 20160895 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Most commonly, atrial fibrillation is triggered by rapid bursts of electrical impulses originating in the myocardial sleeves of pulmonary veins (PVs). However, the nature of such bursts remains poorly understood. Here, we propose a mechanism of bursting consistent with the extensive empirical information about the electrophysiology of the PVs. The mechanism is essentially non-local and involves the spontaneous initiation of non-sustained spiral waves in the distal end of the muscle sleeves of the PVs. It reproduces the experimentally observed dynamics of the bursts, including their frequency, their intermittent character, and the unusual shape of the electrical signals in the pulmonary veins that are reminiscent of so-called early afterdepolarizations (EADs). |
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Authors:
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Christian W Zemlin; Bogdan G Mitrea; Arkady M Pertsov |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Physica D. Nonlinear phenomena Volume: 238 ISSN: 0167-2789 ISO Abbreviation: - Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2010-7-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9890573 Medline TA: Physica D Country: - |
Other Details:
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Languages: ENG Pagination: 969-975 Citation Subset: - |
Affiliation:
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Department of Pharmacology, SUNY Upstate Medical University, Syracuse, New York 13210, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 HL071762-05A2//NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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