Document Detail


Spontaneous onset of atrial fibrillation.
MedLine Citation:
PMID:  20160895     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Most commonly, atrial fibrillation is triggered by rapid bursts of electrical impulses originating in the myocardial sleeves of pulmonary veins (PVs). However, the nature of such bursts remains poorly understood. Here, we propose a mechanism of bursting consistent with the extensive empirical information about the electrophysiology of the PVs. The mechanism is essentially non-local and involves the spontaneous initiation of non-sustained spiral waves in the distal end of the muscle sleeves of the PVs. It reproduces the experimentally observed dynamics of the bursts, including their frequency, their intermittent character, and the unusual shape of the electrical signals in the pulmonary veins that are reminiscent of so-called early afterdepolarizations (EADs).
Authors:
Christian W Zemlin; Bogdan G Mitrea; Arkady M Pertsov
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Physica D. Nonlinear phenomena     Volume:  238     ISSN:  0167-2789     ISO Abbreviation:  -     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2010-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9890573     Medline TA:  Physica D     Country:  -    
Other Details:
Languages:  ENG     Pagination:  969-975     Citation Subset:  -    
Affiliation:
Department of Pharmacology, SUNY Upstate Medical University, Syracuse, New York 13210, USA.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 HL071762-05A2//NHLBI NIH HHS

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