| Spontaneous onset of complex regional pain syndrome. | |
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MedLine Citation:
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PMID: 19793666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Complex Regional Pain Syndrome (CRPS) usually develops after a noxious event, but spontaneous onsets have been described in 3-11% of the cases. The existence of spontaneous-onset CRPS is highly debated and the aim of the present study was therefore to compare the phenotypic characteristics of CRPS patients with a spontaneous onset, with those of patients with a trauma-induced onset. Data of 537 CRPS patients followed up at four departments of anesthesiology were analyzed and comprised 498 (93%) patients with and 39 (7%) patients without a known eliciting event. There where no significant differences between the two groups in gender, or in onset in upper or lower limb or left or right side of the body. Compared to CRPS patients with a trauma-induced onset, spontaneous-onset cases were on average 9 years younger at disease onset and had a 1.4 years longer median disease duration. No significant differences in frequency were found for any of the 34 compared signs and symptoms when the effect of multiple testing was controlled. In conclusion, CRPS may develop both with and without a precipitating noxious event, with both groups exhibiting a largely similar clinical presentation. Spontaneous-onset CRPS patients generally develop the syndrome at a younger age, possibly indicating a susceptibility to develop the condition. The longer disease duration in spontaneous-onset cases may reflect a more gradual disease onset, poorer prognosis, or a delay in diagnosis, possibly as a result of reluctance to make this diagnosis in the absence of a clear initiating event. |
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Authors:
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Annetje M de Rooij; Roberto S G M Perez; Frank J Huygen; Frank van Eijs; Maarten van Kleef; Martin C R Bauer; Jacobus J van Hilten; Johan Marinus |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-29 |
Journal Detail:
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Title: European journal of pain (London, England) Volume: 14 ISSN: 1532-2149 ISO Abbreviation: Eur J Pain Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-11 Completed Date: 2010-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9801774 Medline TA: Eur J Pain Country: England |
Other Details:
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Languages: eng Pagination: 510-3 Citation Subset: IM |
Copyright Information:
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Copyright 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Chi-Square Distribution Databases, Factual Female Humans Male Middle Aged Pain Measurement Quality of Life* Questionnaires Reflex Sympathetic Dystrophy / diagnosis* Severity of Illness Index |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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