Document Detail

Spontaneous occurrence of photoageing-like phenotypes in the dorsal skin of old SAMP1 mice, an oxidative stress model.
MedLine Citation:
PMID:  23278896     Owner:  NLM     Status:  In-Data-Review    
Skin photoageing is a complex, multifactorial process and both intrinsic and extrinsic factors may contribute to its pathogenesis. The ultraviolet-irradiated hairless mouse has been used as an animal model for photoageing, but this model mimics only the 'extrinsic' aspects. Here, we show that skin from old SAMP1 mice, a model for higher oxidative stress and senescence acceleration, exhibited histological and gene expression changes similar to those in human photoaged skin without ultraviolet irradiation. These changes include an increase in elastic fibre and glycosaminoglycan histologically, an upregulation of several proinflammatory cytokines and matrix metalloproteinases, and an increase in lipid peroxide. We propose that SAMP1 mice are a spontaneous animal model for photoageing caused by an exaggerated intrinsic mechanism, namely, higher oxidative status. This mouse model is useful to explore the link between oxidative stress and photoageing, and to evaluate the efficacy of antioxidants.
Masaaki Sakura; Yoichi Chiba; Emi Kamiya; Ayako Furukawa; Noriko Kawamura; Masanao Niwa; Minoru Takeuchi; Masanori Hosokawa
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Experimental dermatology     Volume:  22     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  62-4     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Fundamental Research Laboratory, General Research & Development Institute, Hoyu Co., Ltd, Nagakute, Aichi, Japan; Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan; Faculty of Life Science, Kyoto Sangyo University, Kyoto, Japan.
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