Document Detail


Spontaneous occlusion of the circle of Willis (moyamoya syndrome).
MedLine Citation:
PMID:  7166015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three young autopsy and four temporal artery biopsy cases with an arteriographically typical moyamoya syndrome were studied by histologic, electron microscopic, and immunofluorescence methods. In all autopsy cases the intracranial segment of the internal carotid arteries showed concentric intimal thickening with severe stenosis or obstruction of the lumen, folding of the internal elastic lamina, and shrinkage of the external diameter of the vessel. Inflammatory infiltration was absent. Abnormal networks of thin-walled vessels, interpreted as secondary collaterals, were seen at the base and on the convexity of the brain. Degenerative changes, including a ruptured coronary aneurysm in one case, were also noted in the coronary and temporal arteries. In both the intra- and extracranial arteries repeated endothelial damage was indicated by the presence of redundant subendothelial basement membrane-like material. Lipid or calcium deposits were exceptional, and no evidence for the presence of immunoglobulins or components of the complement could be obtained by immunofluorescence. These pathologic alterations, distinct from atherosclerosis, fibromuscular dysplasia, and the established types of arteritis, seem to be identical in children and adults, in spite of different clinical manifestations of the moyamoya syndrome in these age groups. We suggest that a humoral factor, associated with infections, may induce repeated endothelial damage and intimal thickening in the intracranial arteries of genetically predisposed children in analogy with recent observations made in the coronary arteries of young subjects.
Authors:
M Haltia; M Iivanainen; H Majuri; M Puranen
Related Documents :
3178425 - Inflammatory aneurysm of the aorta, aortitis, and coronary arteritis.
8774165 - Arterial wall thickness measurements by b mode ultrasonography in patients with takayas...
17698225 - Multiple bailout interventions in a case of takayasu's arteritis.
7077375 - Posterior circulation revascularization. superficial temporal artery to superior cerebe...
21686855 - Bilateral ophthalmic artery occlusion.
2451315 - Double inlet left ventricular main chamber, subaortic small left sided right ventricle ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical neuropathology     Volume:  1     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:  1982  
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  11-22     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Arterial Occlusive Diseases / diagnosis*
Atrophy
Basilar Artery / pathology
Brain / pathology
Carotid Artery, Internal / radiography
Cerebral Angiography
Cerebral Arteries / pathology,  ultrastructure
Child
Child, Preschool
Female
Humans
Infant
Male
Microscopy, Electron
Middle Aged
Moyamoya Disease / diagnosis*
Temporal Arteries / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Blood pressure overshoot under pentobarbitone anaesthesia following a single dose of clonidine in ra...
Next Document:  On the association of excess glycogen granules and polyglucosan bodies (corpora amylacea) in astrocy...