Document Detail

Spontaneous normalization of thyrotropin concentrations in patients with subclinical hypothyroidism.
MedLine Citation:
PMID:  15811925     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Patients with subclinical hypothyroidism may revert to normal TSH values. OBJECTIVE: The objective of this study was to examine the time course of the normalization of TSH levels in subclinical hypothyroidism. DESIGN: This was a prospective, observational study with no intervention, with a duration of follow-up of 12-72 months. SETTING: Outpatients visited an endocrinology clinic of a general hospital. PATIENTS: Forty patients (32 women, mean age 62.8 +/- 8.2 yr) with spontaneous subclinical hypothyroidism (TSH > 5 mU/liter and normal free T(4)) participated in the study. Each patient normalized their TSH values without T(4) therapy throughout the follow-up. MEASUREMENTS: TSH and free T(4) levels were evaluated every 6 months. RESULTS: Normalization occurred at a median time of 18 months (range, 6-60 months). Fifteen patients normalized their TSH levels during the first year of follow-up and 27 during the first 2 yr. Ten patients normalized their TSH values at the fourth or fifth year. Only four patients reverted to TSH values less than 2 mU/liter. Final TSH levels achieved by the patients were significantly correlated with the time elapsed until normalizing these levels (r = 0.367; P = 0.020). CONCLUSIONS: There is no clear pattern of TSH normalization, although most patients normalize their TSH values early in the follow-up. The final TSH reached seems to be related to the time of normalization.
Juan J Díez; Pedro Iglesias; Kenneth D Burman
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Publication Detail:
Type:  Journal Article     Date:  2005-04-05
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  90     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-08     Completed Date:  2005-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4124-7     Citation Subset:  AIM; IM    
Department of Endocrinology, Hospital Ramón y Cajal, Carretera Colmenar km 9, 28034 Madrid, Spain.
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MeSH Terms
Autoantibodies / blood
Hypothyroidism / blood*
Iodide Peroxidase / immunology
Middle Aged
Reference Values
Thyrotropin / blood*
Reg. No./Substance:
0/Autoantibodies; 9002-71-5/Thyrotropin; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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