| Spontaneous normalization of thyrotropin concentrations in patients with subclinical hypothyroidism. | |
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MedLine Citation:
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PMID: 15811925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Patients with subclinical hypothyroidism may revert to normal TSH values. OBJECTIVE: The objective of this study was to examine the time course of the normalization of TSH levels in subclinical hypothyroidism. DESIGN: This was a prospective, observational study with no intervention, with a duration of follow-up of 12-72 months. SETTING: Outpatients visited an endocrinology clinic of a general hospital. PATIENTS: Forty patients (32 women, mean age 62.8 +/- 8.2 yr) with spontaneous subclinical hypothyroidism (TSH > 5 mU/liter and normal free T(4)) participated in the study. Each patient normalized their TSH values without T(4) therapy throughout the follow-up. MEASUREMENTS: TSH and free T(4) levels were evaluated every 6 months. RESULTS: Normalization occurred at a median time of 18 months (range, 6-60 months). Fifteen patients normalized their TSH levels during the first year of follow-up and 27 during the first 2 yr. Ten patients normalized their TSH values at the fourth or fifth year. Only four patients reverted to TSH values less than 2 mU/liter. Final TSH levels achieved by the patients were significantly correlated with the time elapsed until normalizing these levels (r = 0.367; P = 0.020). CONCLUSIONS: There is no clear pattern of TSH normalization, although most patients normalize their TSH values early in the follow-up. The final TSH reached seems to be related to the time of normalization. |
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Authors:
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Juan J Díez; Pedro Iglesias; Kenneth D Burman |
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Publication Detail:
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Type: Journal Article Date: 2005-04-05 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 90 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-08 Completed Date: 2005-08-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 4124-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Endocrinology, Hospital Ramón y Cajal, Carretera Colmenar km 9, 28034 Madrid, Spain. mibarsd@infomed.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Autoantibodies / blood Female Humans Hypothyroidism / blood* Iodide Peroxidase / immunology Male Middle Aged Reference Values Thyrotropin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 9002-71-5/Thyrotropin; EC 1.11.1.8/Iodide Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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