Document Detail


Spontaneous mitral valve prolapse in a breeding colony of rhesus monkeys.
MedLine Citation:
PMID:  3964716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitral valve prolapse was observed in 26 of 92 animals in a harem breeding colony of rhesus monkeys (Macaca mulatta). The affected animals had a systolic murmur best auscultated over the mitral region with the animal in a sitting position. Mid-to-late systolic clicks were also heard. Phonocardiographic examination also demonstrated systolic murmurs and clicks in six of 16 animals. Twenty-three of the animals were studied by M mode and/or two-dimensional echocardiography. The diagnosis was confirmed in 12 animals that had a murmur during the examination. Electrocardiograms revealed T wave abnormalities in five animals and left or right ventricular hypertrophy in five. Four adult animals that died during the course of the study were confirmed at necropsy as having prolapse of the posterior and/or anterior mitral valve leaflets into the atrium. Analysis of the breeding records suggested that mitral valve prolapse was a dominant genetic trait with an approximate birth incidence of 16% to 20% in the colony. The existence of mitral valve prolapse in a nonhuman primate species provides a unique opportunity to study the disease in an experimental animal.
Authors:
M M Swindle; J R Blum; S D Lima; J L Weiss
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  71     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-01-18     Completed Date:  1985-01-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  146-53     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autopsy / veterinary
Echocardiography / veterinary
Electrocardiography / veterinary
Female
Heart Murmurs / veterinary
Ketamine
Macaca / anatomy & histology*
Macaca mulatta / anatomy & histology*,  genetics
Male
Mitral Valve Prolapse / diagnosis,  genetics,  veterinary*
Monkey Diseases / diagnosis,  genetics
Pedigree
Phonocardiography / veterinary
Grant Support
ID/Acronym/Agency:
2P50HL17655-06/HL/NHLBI NIH HHS; RR00130/RR/NCRR NIH HHS; RR07002/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
6740-88-1/Ketamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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