Document Detail


Spontaneous and lectin-induced redistribution of cell surface receptors on embryonic chick neural retina cells.
MedLine Citation:
PMID:  1238408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mobility of plant lectin receptors in the plane of the membrane is examined for cells prepared from embryonic chick neural retinas by a variety of procedures. Cells liberated from the intact tissue by trypsin treatment followed by mechanical dissociation are able to redistribute their receptors into 'caps' both spontaneously and in the presence of a multivalent lectin. These cells, dispersed by trypsinization, upon repair in culture for a suitable period of time lose their ability to redistribute lectin receptors. Cells dispersed by mechanical means without prior trypsin treatment are unable to undergo 'cap' formation. In addition, cells within intact tissues are also unable to redistribute their lectin receptors into 'caps.' Based on these observations we propose that within solid tissues which have assumed their characteristic architecture, cell surfaces are immobilized, and that this phenomenon may be a critical parameter in determining the potential of a cell to undergo morphogenetic rearrangements.
Authors:
J McDonough; J Lilien
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cell science     Volume:  19     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-01     Completed Date:  1976-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  357-68     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / drug effects*,  ultrastructure
Chick Embryo
Fluoresceins
Lectins / pharmacology*
Microscopy, Fluorescence
Receptors, Drug*
Retina / drug effects*,  innervation,  ultrastructure
Trypsin
Chemical
Reg. No./Substance:
0/Fluoresceins; 0/Lectins; 0/Receptors, Drug; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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