Document Detail

Spontaneous labor increases nitric oxide synthesis during the early neonatal period.
MedLine Citation:
PMID:  11472575     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This paper aimed to assess the influence of spontaneous labor upon endogenous nitric oxide (NO) and endothelin 1 (ET-1) during transition to extrauterine life. METHODS: The serum levels of NO metabolites (the sum of nitrites and nitrates (NOx)) and the plasma level of ET-1 were determined in 53 healthy full-term infants (spontaneous labor group; n=40, cesarean delivery group; n=13). In both groups, blood samples were obtained from a cord vein at birth and from a peripheral vein at 5 days of age. RESULTS: The differences in serum NOx concentrations between the spontaneous labor group and the elective cesarean group were not significant at birth. By the age of 5 days, serum NOx concentrations had risen significantly in the spontaneous labor group to become significantly higher in the elective cesarean group. CONCLUSION: It is speculated that spontaneous labor might enhance endogenous NO synthesis at 5 days of age.
A Endo; H Izumi; M Ayusawa; M Minato; S Takahashi; K Harada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  43     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-26     Completed Date:  2001-10-04     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  340-2     Citation Subset:  IM    
Division of Pediatrics, Itabashi Ward Medical Association Hospital, Tokyo, Japan.
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MeSH Terms
Adaptation, Physiological
Blood Circulation / physiology
Cesarean Section
Endothelin-1 / biosynthesis*,  blood
Infant, Newborn / blood*
Labor, Obstetric / physiology*
Nitric Oxide / biosynthesis*,  blood
Reg. No./Substance:
0/Endothelin-1; 10102-43-9/Nitric Oxide

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