Document Detail

Spontaneous intracerebral hemorrhage in humans: hematoma enlargement, clot lysis, and brain edema.
MedLine Citation:
PMID:  16671430     Owner:  NLM     Status:  MEDLINE    
Early hematoma enlargement and delayed clot lysis contribute to brain injury after intracerebral hemorrhage (ICH). We investigated hematoma growth, clot lysis, and brain edema formation in patients with spontaneous ICH. A total of 17 spontaneous ICH patients who received regular medication were chosen for this study. All patients had their first CT scan within 5 hours of onset of symptoms (day 0). The patients then underwent second, third, and fourth CT scans at 1, 3, and 10 days later. Hematoma size and absolute and relative brain edema volumes were measured. Hematoma enlargement was defined as a > 33% increase in volume. Relative brain edema volume = absolute brain edema volume/hematoma size. Hematoma enlargement occurred in 4 of the 17 ICH patients (24%) within the first 24 hours. The hematoma sizes were reduced significantly at day 10 (p < 0.05) because of clot lysis. However, both absolute and relative brain edema increased gradually with time (p < 0.01). These results suggest that delayed brain edema following ICH may result from hematoma lysis. This study also shows that early hematoma enlargement occurs in Chinese patients with ICH. Reducing early hematoma growth and limiting clot lysis-induced brain toxicity could be potential therapies for ICH.
G Wu; G Xi; F Huang
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  96     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-04     Completed Date:  2006-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  78-80     Citation Subset:  IM    
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
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MeSH Terms
Brain Edema / etiology,  prevention & control*,  radiography*
Cerebral Hemorrhage / complications,  drug therapy*,  radiography
Fibrinolytic Agents / therapeutic use*
Middle Aged
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents

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