| Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice. | |
| | |
MedLine Citation:
|
PMID: 19724290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Oxidative stress and matrix metalloproteinases (MMPs) contribute to hemorrhagic transformation after ischemic stroke and brain injury after intracerebral hemorrhage (ICH). The goal of this study was to develop a new model of spontaneous ICH, based on the hypothesis that acute, superimposed on chronic, hypertension produces ICH. We hypothesized that increases in angiotensin II (AngII)-mediated oxidative stress and activation of MMPs are associated with, and may precede, spontaneous ICH during hypertension. In C57BL/6 mice, chronic hypertension was produced with AngII infusion and an inhibitor of nitric oxide synthase. During chronic hypertension, mice with acute hypertension from injections of AngII developed ICH. Oxidative stress and MMP levels increased in the brain even before developing ICH. Active MMPs colocalized with a marker of oxidative stress, especially on cerebral vessels that appeared to lead toward regions with ICH. Incidence of ICH and levels of oxidative stress and MMP-9 were greater in mice with acute hypertension produced by AngII than by norepinephrine. In summary, we have developed an experimental model of ICH during hypertension that may facilitate studies in genetically altered mice. We speculate that acute hypertension, especially when induced by AngII, may be critical in spontaneous ICH during chronic hypertension, possibly through oxidative stress and MMP-9. |
| | |
Authors:
|
Yoshinobu Wakisaka; Yi Chu; Jordan D Miller; Gary A Rosenberg; Donald D Heistad |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-09-02 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-01-04 Completed Date: 2010-02-03 Revised Date: 2011-07-20 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 56-69 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Angiotensin II Animals Blood Pressure / physiology Chronic Disease Fluorescent Antibody Technique Gelatin Hypertension / chemically induced, complications*, pathology Immunohistochemistry Intracranial Hemorrhages / etiology*, pathology Male Matrix Metalloproteinases / metabolism Mice Mice, Inbred C57BL Norepinephrine Oxidative Stress / drug effects Reverse Transcriptase Polymerase Chain Reaction Stroke / pathology Vasoconstrictor Agents |
| Grant Support | |
ID/Acronym/Agency:
|
F32 HL086160-02/HL/NHLBI NIH HHS; HL62984/HL/NHLBI NIH HHS; K99 HL092235-01/HL/NHLBI NIH HHS; NS24621/NS/NINDS NIH HHS; R00 HL092235-02/HL/NHLBI NIH HHS; R00 HL092235-03/HL/NHLBI NIH HHS; R00 HL092235-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 51-41-2/Norepinephrine; 9000-70-8/Gelatin; EC 3.4.24.-/Matrix Metalloproteinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vivo assessment of macrophage CNS infiltration during disruption of the blood-brain barrier with ...
Next Document: Is the association of type II diabetes with waist circumference or waist-to-hip ratio stronger than ...