Document Detail

Spontaneous and induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members.
MedLine Citation:
PMID:  2456871     Owner:  NLM     Status:  MEDLINE    
Detailed chromosome analysis failed to reveal any evidence for spontaneous chromosome instability in lymphocytes from patients with multiple endocrine neoplasia, type 2 (MEN-2), whereas, with one exception, lymphocytes from MEN-2 patients were significantly more sensitive to chromosome damage by bleomycin and, to a lesser extent, MNNG than those from controls. The exceptional case suggests possible genetic heterogeneity in MEN-2.
K Tsioupra; L F West; M B Davis; J M Parrington; J D Delhanty
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease markers     Volume:  6     ISSN:  0278-0240     ISO Abbreviation:  Dis. Markers     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-09-19     Completed Date:  1988-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
University College London, Department of Genetics and Biometry.
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MeSH Terms
Bleomycin / pharmacology
Carcinoma / genetics*
Chromosome Aberrations*
Lymphocytes / analysis*,  drug effects
Methylnitronitrosoguanidine / pharmacology
Multiple Endocrine Neoplasia / genetics*
Thyroid Neoplasms / genetics*
Reg. No./Substance:
11056-06-7/Bleomycin; 70-25-7/Methylnitronitrosoguanidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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