Document Detail

Spontaneous histamine release in whole blood in patients before and after 4 months of specific immunotherapy.
MedLine Citation:
PMID:  10779291     Owner:  NLM     Status:  MEDLINE    
Spontaneous histamine release (SHR) in whole blood was assessed before and after 4 months of specific immunotherapy (SIT) for allergic rhinoconjunctivitis in 32 patients. Spontaneous histamine release was significantly enhanced (P < 0.05) in patients prior to immunotherapy compared with 20 controls. Spontaneous histamine release decreased significantly in patients after 4 months of specific immunotherapy (P < 0.04) and almost reached the same values as spontaneous histamine release in controls. Clinical success of treatment after 4 months was seen in 15 patients (improvement > or =50%), 10 of whom showed a significant decrease in spontaneous histamine release. Decrease of spontaneous histamine release after 4 months indicates the efficacy of specific immunotherapy already at an early stage of treatment. Assessment of spontaneous histamine release appears to be a useful and easily performable method for monitoring success of treatment of patients during specific immunotherapy.
F Wantke; M Götz; R Jarisch
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  23     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  1993 Dec 
Date Detail:
Created Date:  2000-06-19     Completed Date:  2000-06-19     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  992-5     Citation Subset:  IM    
Dermatologic and Pediatric Allergy Clinic, Vienna, Austria.
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MeSH Terms
Conjunctivitis, Allergic / blood,  therapy*
Desensitization, Immunologic*
Histamine Release*
Rhinitis, Allergic, Seasonal / blood,  therapy*
Treatment Outcome

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