Document Detail

Spontaneous heart rate, propranolol, and ischaemia-induced ventricular fibrillation in the dog.
MedLine Citation:
PMID:  750078     Owner:  NLM     Status:  MEDLINE    
Abrupt coronary occlusion was performed in anaesthetised, open-chest dogs with pre-occlusion arterial blood PO2 ranging from 8.0 to 10.7 kPa (60 to mmHg). Ventricular fibrillation occurred in 15/19 dogs with high spontaneous heart rate (less than 155 beats.min-1) and in 0/8 dogs with low spontaneous heart rate (less than 155 beats.min-1). Dogs with low spontaneous heart rate fibrillated when paced at a fast rate (200.min-1) (4/5). In dogs with high spontaneous heart rate fibrillation occurred in 0/5 dogs when propranolol reduced spontaneous heart rate, but in 3/5 dogs when reduction in spontaneous heart rate in response to propranolol was prevented by pacing.
R D Reynolds; S V Calzadilla; R J Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  12     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  653-8     Citation Subset:  IM    
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MeSH Terms
Coronary Disease / complications
Heart Rate* / drug effects
Propranolol / pharmacology*
Ventricular Fibrillation / etiology*,  physiopathology
Reg. No./Substance:

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