| Spontaneous and ethyl methanesulfonate-induced mutations controlling viability in Drosophila melanogaster. III. Heterozygous effect of polygenic mutations. | |
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MedLine Citation:
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PMID: 200527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spontaneous and EMS-induced mutations were accumulated for several generations on the second chromosome of Drosophila melanogaster by keeping this chromosome heterozygous under conditions of minimal natural selection. This article reports studies of heterozygous effects of these mutants.--Both lethal and mildly deleterious mutants have a deleterious heterozygous effect. There was no discernible difference between heterozygotes in which all the mutants were on one chromosome and those where the mutants were distributed over both homologs; thus the coupling-repulsion effect of MUKAI and YAMAZAKI (1964, 1968) is not confirmed. The spontaneous polygenic mutants have a dominance of 0.4 to 0.5, and the same value is found at very low EMS doses. However, the value at higher EMS doses is only about half as high. Since the low doses have a large fraction of spontaneous mutants, the dominance of EMS mutants is less, in the range 0.1 to 0.3, but still larger than for lethals. |
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Authors:
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O Ohnishi |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Genetics Volume: 87 ISSN: 0016-6731 ISO Abbreviation: Genetics Publication Date: 1977 Nov |
Date Detail:
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Created Date: 1978-01-27 Completed Date: 1978-01-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0374636 Medline TA: Genetics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 547-56 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drosophila melanogaster / drug effects, genetics* Ethyl Methanesulfonate / pharmacology* Female Genes Genes, Dominant Genes, Lethal Heterozygote Male Mesylates / pharmacology* Mutation* Probability |
| Chemical | |
Reg. No./Substance:
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0/Mesylates; 62-50-0/Ethyl Methanesulfonate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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