Document Detail


Spontaneous echo-contrast as an in vivo indicator of rheological imbalance in dilatative cardiomyopathy.
MedLine Citation:
PMID:  11847414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate coagulative and hemorheologic assessment in patients with dilatative cardiomyopathy with or without spontaneous echo contrast (SEC). We studied 45 patients, 35 males and 10 females (mean age 72.1 +/- 9.2). We measured whole blood viscosity, plasmatic fibrinogen, prothrombin time (PT), activated partial thromboplastin time (aPTT), D-dimer and red cell morphology with Zipursky-Forconi method. Transthoracic and transesophageal echocardiography was performed in all patients to evaluate the presence of SEC in left atrium. We divided all the patients into two groups: the 1st group of 20 patients with SEC and Atrial Fibrillation (AF) in 80% of cases, and the 2nd group of 25 patients without SEC and AF in 31%. Our results show that in patients with SEC there is a statistically significant increase of whole blood viscosity and plasma fibrinogen in comparison with patients without SEC. Red cell morphology in all patients demonstrates a reversed EMI. D-Dimer, was out of the normal range in about 1/3 of the patients in both groups. An analysis of our results points out that in patients with SEC and AF, with a major risk factor for cardioembolic stroke, we have alterations of hemorheologic assessment with an increase of whole blood viscosity and fibrinogen that seems to be caused by an increase of red cells aggregability favoured by fibrinogen. Our conclusions are that SEC in patients with dilatative cardiomyopathy and AF is an important in vivo indicator of hemorheologic imbalance and an important marker for cardioembolic risk stroke evaluation.
Authors:
V Turchetti; M A Bellini; D Ricci; A Lapi; G Donati; L Boschi; L Trabalzini; M Guerrini; S Forconi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  25     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2001  
Date Detail:
Created Date:  2002-03-06     Completed Date:  2002-05-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  119-25     Citation Subset:  IM    
Affiliation:
Institute of Internal Medicine and Geriatrics, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy. images@unisi.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Atrial Fibrillation / blood,  complications,  drug therapy,  ultrasonography
Blood Viscosity
Cardiomyopathy, Dilated / blood,  complications,  drug therapy,  ultrasonography*
Cardiovascular Agents / therapeutic use
Echocardiography, Transesophageal*
Erythrocytes / ultrastructure
Female
Fibrin Fibrinogen Degradation Products / analysis
Fibrinogen / analysis
Heart Atria / pathology,  ultrasonography
Hematocrit
Hemorheology*
Humans
Male
Middle Aged
Partial Thromboplastin Time
Prothrombin Time
Risk Factors
Stroke / blood,  epidemiology
Stroke Volume
Chemical
Reg. No./Substance:
0/Cardiovascular Agents; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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