Document Detail

Spontaneous diabetes mellitus in young cattle: histologic, immunohistochemical, and electron microscopic studies of the islets of Langerhans.
MedLine Citation:
PMID:  8442327     Owner:  NLM     Status:  MEDLINE    
Pathomorphologic studies were carried out on three cases of bovine diabetes mellitus with clinical signs of polydipsia, polyuria, severe emaciation, glycosuria, persistent hyperglycemia, and decreased glucose tolerance. At necropsy, two animals had atrophy of the pancreas, whereas other visceral organs, including the endocrine organs, showed no significant changes. Microscopically, there was atrophy and reduced numbers of pancreatic islets accompanied by interlobular and interacinar fibrosis and compensatory enlargement of some remaining islets. Lymphocytes were observed commonly around and within atrophic islets and occasionally around and within enlarged islets. Vacuolar degeneration with occasional accumulation of glycogen granules was observed in the beta-cells of these enlarged islets. Immunohistochemical studies of atrophic islets demonstrated complete loss of beta-cells or only a few small beta-cells. There also was a corresponding decrease in the number of cells that stained with anti-glucagon (alpha-cells) or anti-somatostatin (delta-cells) antibodies. The vacuolated cells in the enlarged islets stained strongly with anti-insulin antibody (beta-cells). Ultrastructurally, the majority of cells in the atrophic islets had reduced cytoplasmic volume and few secretory granules, features consistent with alpha-cells. In contrast, enlarged islets that had prominent immunohistochemical staining for insulin (beta-cells) consisted of beta-cells with cytosolic edema, mitochondrial swelling, dilated smooth endoplasmic reticulum, and reduced numbers of or degranulated secretory granules. These pathomorphologic features found in cattle are similar to those found in juvenile-onset insulin-dependent diabetes mellitus in human beings and suggest autoimmune involvement in diabetes.
H Taniyama; T Shirakawa; H Furuoka; S Osame; N Kitamura; K Miyazawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  30     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-29     Completed Date:  1993-03-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  46-54     Citation Subset:  IM    
Department of Veterinary Pathology, Rakuno Gakuen University, Hokkaido, Japan.
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MeSH Terms
Cattle Diseases / pathology*
Cell Count / veterinary
Diabetes Mellitus / pathology,  veterinary*
Islets of Langerhans / pathology*,  ultrastructure
Microscopy, Electron / veterinary

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