Document Detail


Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats.
MedLine Citation:
PMID:  7699997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.
Authors:
C E Whitworth; S Fleming; A D Cumming; J J Morton; N J Burns; B C Williams; J J Mullins
Related Documents :
8104577 - Renin suppressibility and blood pressure response during acute sodium loading in patien...
6756697 - Active and inactive renin during acute reduction of renal perfusion pressure in essenti...
6400117 - Humoral changes during and following coronary bypass surgery: relationship to postopera...
6025477 - Renin release during acute reduction of arterial pressure in normotensive subjects and ...
8104577 - Renin suppressibility and blood pressure response during acute sodium loading in patien...
2274717 - Reexamination of the elastic properties of emphysematous lungs.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  46     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-03     Completed Date:  1995-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1528-32     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Edinburgh, Scotland, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Blood Pressure / genetics
Disease Models, Animal
Female
Heterozygote
Humans
Hypertension, Malignant / etiology*,  genetics*,  pathology
Kidney / pathology
Male
Phenotype
Rats
Rats, Inbred Lew
Rats, Sprague-Dawley
Sodium, Dietary / administration & dosage
Chemical
Reg. No./Substance:
0/Sodium, Dietary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Proteolytic processing of human prorenin in renal and non-renal tissues.
Next Document:  Cortical expression of the human angiotensinogen gene in the kidney of transgenic mice.