Document Detail

Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats.
MedLine Citation:
PMID:  7699997     Owner:  NLM     Status:  MEDLINE    
Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.
C E Whitworth; S Fleming; A D Cumming; J J Morton; N J Burns; B C Williams; J J Mullins
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  46     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-03     Completed Date:  1995-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1528-32     Citation Subset:  IM    
Department of Pathology, University of Edinburgh, Scotland, United Kingdom.
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MeSH Terms
Animals, Genetically Modified
Blood Pressure / genetics
Disease Models, Animal
Hypertension, Malignant / etiology*,  genetics*,  pathology
Kidney / pathology
Rats, Inbred Lew
Rats, Sprague-Dawley
Sodium, Dietary / administration & dosage
Reg. No./Substance:
0/Sodium, Dietary

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