Document Detail

Spontaneous decline in exercise-induced proteinuria during a 100-mile triathlon.
MedLine Citation:
PMID:  2402649     Owner:  NLM     Status:  MEDLINE    
To study the effect of prolonged exercise on glomerular permeability and proteinuria, we collected serial urine samples from six athletes during a 100-mile triathlon. Urine collected just before, at the midpoint of, and immediately after the race was analyzed for creatinine by an automated chemistry analyzer, pack method, and for microalbumin by radioimmunoassay. By midrace, the urinary albumin-creatinine ratio increased from the prerace mean +/- SEM of 3.5 +/- 0.5 to 38.3 +/- 11.7 mg/g. The ratio then declined to 12.5 +/- 2.7 mg/g by the end of the race (P less than .04). Similarly, the urinary albumin level increased significantly from 5.9 +/- 0.7 to 80.5 +/- 26.8 micrograms/mL by midrace, followed by a decline to 39.2 +/- 12.9 micrograms/mL. The initial increase in albuminuria was expected and reflects the increase in exercise-induced cardiac output and glomerular permeability. The subsequent decline in albuminuria and albumin-creatinine ratio, despite continued exercise, was unexpected and indicates a decrease in glomerular permeability. Further study is warranted to determine the mechanism of this apparently protective renal response to prolonged exercise.
T E Edes; J H Shah; W H Thornton
Related Documents :
24888429 - Physical ischemia induced by isometric exercise facilitated collateral development in t...
7780439 - Exercise pad testing in continent exercisers: reproducibility and correlation with void...
3583229 - Reduction of exercise-induced albuminuria by aspirin-dipyridamole in patients with diab...
24714059 - 12-mo intervention of physical exercise improved work ability, especially in subjects w...
2182589 - The human vertebral column at the end of the embryonic period proper. 4. the sacrococcy...
12271229 - Postnatal pelvic floor screening clinics: a pilot study.
9131859 - Does physical fitness influence intraocular pressure?
16226769 - Difference in neuropathogenetic mechanisms in human furious and paralytic rabies.
7350799 - Sites of airway dilatation in asthma following inhaled versus subcutaneous terbutaline....
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  83     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-19     Completed Date:  1990-10-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1044-6, 1052     Citation Subset:  AIM; IM    
Department of Medicine, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Creatinine / blood,  urine
Physical Endurance / physiology*
Physical Exertion / physiology*
Proteinuria / physiopathology*
Reference Values
Remission, Spontaneous
Serum Albumin / metabolism
Reg. No./Substance:
0/Serum Albumin; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Efficacy of sedation of children with chloral hydrate.
Next Document:  Acetaminophen hepatotoxicity in the alcoholic.