Document Detail


Spontaneous decline in exercise-induced proteinuria during a 100-mile triathlon.
MedLine Citation:
PMID:  2402649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study the effect of prolonged exercise on glomerular permeability and proteinuria, we collected serial urine samples from six athletes during a 100-mile triathlon. Urine collected just before, at the midpoint of, and immediately after the race was analyzed for creatinine by an automated chemistry analyzer, pack method, and for microalbumin by radioimmunoassay. By midrace, the urinary albumin-creatinine ratio increased from the prerace mean +/- SEM of 3.5 +/- 0.5 to 38.3 +/- 11.7 mg/g. The ratio then declined to 12.5 +/- 2.7 mg/g by the end of the race (P less than .04). Similarly, the urinary albumin level increased significantly from 5.9 +/- 0.7 to 80.5 +/- 26.8 micrograms/mL by midrace, followed by a decline to 39.2 +/- 12.9 micrograms/mL. The initial increase in albuminuria was expected and reflects the increase in exercise-induced cardiac output and glomerular permeability. The subsequent decline in albuminuria and albumin-creatinine ratio, despite continued exercise, was unexpected and indicates a decrease in glomerular permeability. Further study is warranted to determine the mechanism of this apparently protective renal response to prolonged exercise.
Authors:
T E Edes; J H Shah; W H Thornton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  83     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-19     Completed Date:  1990-10-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1044-6, 1052     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201.
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MeSH Terms
Descriptor/Qualifier:
Adult
Creatinine / blood,  urine
Humans
Physical Endurance / physiology*
Physical Exertion / physiology*
Proteinuria / physiopathology*
Reference Values
Remission, Spontaneous
Serum Albumin / metabolism
Sports*
Chemical
Reg. No./Substance:
0/Serum Albumin; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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