Document Detail

Spontaneous course of Wegener's granulomatosis
MedLine Citation:
PMID:  3361797     Owner:  NLM     Status:  MEDLINE    
Two cases of Wegener's granulomatosis are reported. During the 5 and 9 years course of the disease complete remissions and the disappearance of pulmonary opacities were found without specific treatment. Since 1970 cytotoxic drugs, e.g. cyclophosphamide, are frequently used for the treatment of Wegener's granulomatosis. The evaluation of the follow-up showed in these patients that in most cases the side-effects of the therapy, and not the primary disease, limited the life-expectancy. This especially applies for patients with mild forms of Wegener's granulomatosis, in which the initiation of a cytotoxic therapy should carefully be evaluated.
O Adam; H Wiesinger
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  66     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-07     Completed Date:  1988-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  ger     Pagination:  181-6     Citation Subset:  IM    
Medizinische Poliklinik der Universität München.
Vernacular Title:
Spontanverläufe der Wegenerschen Granulomatose.
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MeSH Terms
Aged, 80 and over
Cyclophosphamide / administration & dosage
Drug Therapy, Combination
Lung / pathology
Lung Diseases / pathology
Maxillary Sinus / pathology
Middle Aged
Orbit / pathology
Orbital Diseases / pathology
Paranasal Sinus Diseases / pathology
Prednisone / administration & dosage
Pulmonary Artery / pathology
Wegener Granulomatosis / pathology*
Reg. No./Substance:
50-18-0/Cyclophosphamide; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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