| Spontaneous coronary artery dissection: case series with extended follow up. | |
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MedLine Citation:
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PMID: 21297205 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Spontaneous coronary artery dissection (SCAD) is atherosclerotic or non-atherosclerotic in origin. Eosinophilic infiltrate is identified in coronary artery adventitia in non-atherosclerotic SCAD. We postulate that a systemic inflammatory state causes SCAD in younger women who do not have significant coronary artery disease risk factors. We report a case series of 13 patients presenting with SCAD from ages 26-48 with follow up from 1 month to 13 years. Most patients did not have conventional risk factors for coronary artery disease (CAD). Approximately 50% of the patients developed recurrent dissection within the first 2 weeks of an index event, but < 25% were symptomatic during follow up. All patients were alive at follow up. Systemic inflammatory state was observed in 80% of patients who developed early recurrent dissection. SCAD should be strongly suspected in younger women presenting with acute coronary syndrome without CAD risk factors. Coronary dissection may recur within first 2 weeks, but patients have good long-term survival without new episodes of dissection. Broad rheumatologic and connective tissue disease work-up should be considered in young females presenting with SCAD. |
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Authors:
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Pranav Kansara; Susan Graham |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of invasive cardiology Volume: 23 ISSN: 1557-2501 ISO Abbreviation: J Invasive Cardiol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8917477 Medline TA: J Invasive Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 76-80 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, The State University of New York at Buffalo, Buffalo, NY 14221, USA. pkansara@buffalo.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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