Document Detail

Spontaneous coronary artery dissection by intravascular ultrasound in a patient with myocardial infarction.
Jump to Full Text
MedLine Citation:
PMID:  24574840     Owner:  NLM     Status:  In-Data-Review    
Spontaneous coronary artery dissection is a rare cause of acute coronary syndrome and sudden cardiac death. The incidence, causes, pathogenesis, and treatment have not been defined clearly, but spontaneous coronary artery dissection should be considered in young patients without major cardiovascular risk factors or in patients in the peripartum period who present with acute coronary syndrome. The treatment is often challenging. Medical treatment is usually considered, and percutaneous coronary intervention or coronary artery bypass surgery may be possible in some patients. We herein report two cases of middle-aged males with myocardial infarction who were treated with percutaneous coronary angioplasty.
Ji Hun Jang; Dae Hyeok Kim; Dong Hyuk Yang; Seong Il Woo; Jun Kwan; Keum Soo Park; Sung-Hee Shin
Publication Detail:
Type:  Journal Article     Date:  2014-01-02
Journal Detail:
Title:  The Korean journal of internal medicine     Volume:  29     ISSN:  2005-6648     ISO Abbreviation:  Korean J. Intern. Med.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-02-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712418     Medline TA:  Korean J Intern Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  106-10     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Korean J Intern Med
Journal ID (iso-abbrev): Korean J. Intern. Med
Journal ID (publisher-id): KJIM
ISSN: 1226-3303
ISSN: 2005-6648
Publisher: The Korean Association of Internal Medicine
Article Information
Download PDF
Copyright © 2014 The Korean Association of Internal Medicine
Received Day: 10 Month: 7 Year: 2012
Revision Received Day: 23 Month: 8 Year: 2012
Accepted Day: 04 Month: 10 Year: 2012
Print publication date: Month: 1 Year: 2014
Electronic publication date: Day: 02 Month: 1 Year: 2014
Volume: 29 Issue: 1
First Page: 106 Last Page: 110
PubMed Id: 24574840
ID: 3932380
DOI: 10.3904/kjim.2014.29.1.106

Spontaneous coronary artery dissection by intravascular ultrasound in a patient with myocardial infarction
Ji Hun JangA1
Dae Hyeok KimA1
Dong Hyuk YangA1
Seong Il WooA1
Jun KwanA1
Keum Soo ParkA1
Sung-Hee ShinA1
Division of Cardiology, Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
Correspondence: Correspondence to Sung-Hee Shin, M.D. Division of Cardiology, Department of Internal Medicine, Inha University School of Medicine, 27 Inhang-ro, Jung-gu, Incheon 400-711, Korea. Tel: +82-32-890-2200, Fax: +82-32-890-2447,


Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome and sudden cardiac death. The first case of SCAD was reported by Pretty [1] in 1931, while the first angiographic diagnosis was not made until 1978 [2]. SCAD occurs mostly in female patients during the peripartum period, but it can also occur in patients with atherosclerosis or in patients without any of these features [3,4]. Its incidence, etiology, and pathogenesis remain unclear. The clinical presentation of SCAD depends on the extent and flow-limiting severity of the coronary dissection. The condition ranges from asymptomatic state to the development of unstable angina, acute myocardial infarction, ventricular arrhythmia, and sudden cardiac death. There is no definite guideline on how to manage patients with SCAD [5]. In this report, we describe two patients with myocardial infarction caused by SCAD who were treated with percutaneous coronary intervention (PCI).

Case 1

A 60-year-old male presented with dizziness and chest discomfort. The patient had experienced severe crushing chest pain with sweating 15 years ago. However, the patient did not visit the hospital at that time because the chest pain completely resolved after several hours. He was a 20-pack-year smoker and had been taking a calcium channel blocker, an angiotensin receptor blocker, and a hydrochlorothiazide for hypertension.

Electrocardiography showed the Q wave in the V1, V2, and V3 leads. Transthoracic echocardiography showed akinesia of the mid to apical left ventricular (LV) anteroseptal wall. Cardiac enzymes were within their normal ranges and remained normal throughout the follow-up.

Coronary angiography revealed a dual lumen separated by a flap-like defect, indicative of intimal dissection in the proximal left anterior descending artery (LAD) (Fig. 1A). Intravascular ultrasonography (IVUS) showed an entry intimal tear proximal to the dissection site in the LAD (Fig. 1B). Fig. 1C shows an intimal flap dividing the true lumen from the false one at the dissection site. The false lumen had a larger area than the true lumen. Fig. 1D demonstrates a re-entry intimal tear distal to the dissection site.

Percutaneous coronary angioplasty was performed, and a 4.0 × 22.0-mm everolimus-eluting stent (Xience Prime, Abbott Vascular, Santa Clara, CA, USA) was inserted at the proximal LAD lesion.

Case 2

A 40-year-old male was admitted to our hospital because of frequent chest pain. The patient had experienced severe squeezing chest pain 3 months previously, and he had developed frequent chest discomfort with dyspnea since then.

He was a 20-pack-year smoker. He had been taking a calcium channel blocker, an angiotensin receptor blocker, and statin for hypertension and hyperlipidemia for the past 10 years.

Electrocardiography showed ST elevation in the V1 to V4 leads and reciprocal ST depression in leads II, III, and aVF. Transthoracic echocardiography showed preserved LV global systolic function with no definite regional wall motion abnormality. Cardiac enzymes demonstrated mildly elevated troponin I, which was initially 0.2 ng/mL and peaked at 0.3 ng/mL during the follow-up.

Coronary angiography showed a dual lumen defect, indicative of intimal dissection in the mid LAD (Fig. 2A). The other coronary arteries were angiographically normal. IVUS showed an intimal flap dividing the true lumen and false lumen at the mid LAD site (Fig. 2C and 2D).

Percutaneous coronary angioplasty was performed, and a 4.0 × 22.0-mm zotarolimus-eluting stent (Resolute Integrity, Medtronic, Santa Rosa, CA, USA) was inserted at the mid LAD lesion.

After stent insertion, resolution of the initial dissection area was confirmed angiographically (Fig. 2B).


This report illustrated two cases of myocardial infarction caused by SCAD in middle-aged males who were treated with percutaneous coronary angioplasty.

The incidence of SCAD is low, reportedly 0.07% to 1.10% among patients referred for coronary angiography. It occurs most often in young females (aged < 40 years) and frequently in the peripartum period. Although our cases were more unusual in that they involved SCAD in the LAD of middle-aged males, SCAD is reported to predominantly involve the LAD in females and right coronary artery in males. It has rarely been associated with connective tissue disease, vasculitis, inflammatory disorders, oral contraceptive use, exercise, prolonged sneezing, and cocaine abuse. Thus, it should be suspected in a young patient without major cardiovascular risk factors or in a patient in the peripartum period presenting with acute coronary syndrome or sudden cardiac death [6-10]. Our patients had no underlying conditions, and their SCAD can be considered idiopathic. In addition, SCAD seemed to persist for more than 10 years after myocardial infarction in the first patient. While a weak association between smoking and hypertension has been reported, classic risk factors seem unlikely to be related to SCAD [6]. Coronary atherosclerosis is known to be the most common pathology associated with SCAD. In atherosclerotic arteries, plaques play a central role in the pathogenesis of dissection. Plaques may bleed or rupture, leading to dissection of the adventitia from the media and subsequent rupture of the media. They may also cause intimal tears that progress into the media.

Coronary angiography is essential in the diagnosis of SCAD. The typical appearance is the presence of a thin, longitudinal radiolucent line representing an intimal medial flap with flow in two or more separate lumens. Additional IVUS and optical coherence tomography imaging may provide detailed information on the location and extent of the dissection. Typical IVUS features of SCAD are the presence of an intramural hematoma in the outer third of the media compressing the true lumen with minimal or no atherosclerosis [5,10]. There are two types of SCAD. One is an intimal tear and propagation of medial dissection that can be recognized angiographically, as shown in our cases. The other is medial dissection with hematoma formation, but no intimal tear. Computed tomography coronary angiography can be useful in the follow-up of conservatively managed patients.

Treatment of SCAD is often challenging and may include medical therapy, PCI, or coronary artery bypass graft surgery (CABG). Ongoing ischemia and the disease extent are important considerations when making a decision regarding the most appropriate treatment modality. Medical treatment is a reasonable option in patients with stable hemodynamics, single-vessel SCAD affecting a limited territory, or Thrombolysis In Myocardial Infarction (TIMI) of grade 2 or 3 flow. In patients with completed infarctions without residual ischemic symptoms, medical therapy is reportedly associated with a good long-term outcome. Coronary intervention can be considered as the first-line approach for SCAD complicated by occlusion or significantly slowed flow, especially in cases of proximal dissection or TIMI of grade 0 or 1 f low [3,4,6,10]. CABG may be an optimal treatment choice in multivessel disease or left main vessel disease. In our patients, PCI was performed because both had chest pain suggestive of ongoing ischemia and flow-limiting LAD lesions. During coronary intervention, the surgeon should be cautious about wiring the false lumen because vessel perforation or distal propagation of the dissection may occur; it is important to confirm wiring of the true lumen under intravascular imaging such as IVUS or optical coherence tomography [4,5]. In the present cases, we performed percutaneous coronary angioplasty and stent deployment without complications in patients presenting with myocardial infarction under IVUS. Recent developments in stenting and PCI techniques will make the role of PCI more important in treating SCAD.

In conclusion, SCAD should be considered in patients presenting with acute coronary syndrome with few conventional coronary risk factors. Prompt diagnosis and patient-tailored management may reduce morbidity and mortality in this population.


No potential conflict of interest relevant to this article is reported.

1. Pretty HC. Dissecting aneurysms of coronary artery in a woman aged 42: ruptureBr Med JYear: 19311667
2. Ciraulo DA,Chesne RB. Coronary arterial dissection: an unrecognized cause of myocardial infarction, with subsequent coronary arterial patencyChestYear: 197873677679648228
3. Togni M,Amann FW,Follath F. Spontaneous multivessel coronary artery dissection in a pregnant woman treated successfully with stent implantationAm J MedYear: 199910740740810527054
4. Motreff P,Souteyrand G,Dauphin C,Eschalier R,Cassagnes J,Lusson JR. Management of spontaneous coronary artery dissection: review of the literature and discussion based on a series of 12 young women with acute coronary syndromeCardiologyYear: 2010115101819816020
5. Vrints CJ. Spontaneous coronary artery dissectionHeartYear: 20109680180820448134
6. Pasalodos Pita J,Vazquez Gonzalez N,Perez Alvarez L,Vazquez Rodriguez JM,Castro Beiras A. Spontaneous coronary artery dissectionCathet Cardiovasc DiagnYear: 19943227328039214
7. Jorgensen MB,Aharonian V,Mansukhani P,Mahrer PR. Spontaneous coronary dissection: a cluster of cases with this rare findingAm Heart JYear: 1994127138213878172069
8. Zampieri P,Aggio S,Roncon L,et al. Follow up after spontaneous coronary artery dissection: a report of five casesHeartYear: 1996752062098673763
9. DeMaio SJ Jr,Kinsella SH,Silverman ME. Clinical course and long-term prognosis of spontaneous coronary artery dissectionAm J CardiolYear: 1989644714742773790
10. Thompson EA,Ferraris S,Gress T,Ferraris V. Gender differences and predictors of mortality in spontaneous coronary artery dissection: a review of reported casesJ Invasive CardiolYear: 200517596115640544

Article Categories:
  • Case Report

Keywords: Coronary artery dissection, spontaneous, Myocardial infarction, Coronary angiography, Ultrasonography, interventional, Percutaneous coronary intervention.

Previous Document:  Hepatoduodenal fistula formation following transcatheter arterial chemoembolization and radiotherapy...
Next Document:  Hypothermia-induced acute kidney injury in an elderly patient.