Document Detail

Spontaneous closure of inlet ventricular septal defect in an infant with Down's syndrome and aortic coarctation.
MedLine Citation:
PMID:  8339659     Owner:  NLM     Status:  MEDLINE    
Ventricular septal defect (VSD) is considered one of the most common congenital heart diseases in patients with Down's syndrome. It is well known that some VSDs show a tendency to diminish in size and to close. To our knowledge, in patients with Down's syndrome spontaneous closure of a perimembranous inlet VSD has not been described before. The prevalence of some cardiac malformations and the rarity of others have been reported in patients with Down's syndrome. Left ventricular outflow tract obstruction rarely occurs in patients with Down's syndrome. A case of Down's syndrome with coarctation of the aorta, patent ductus arteriosus, and perimembranous inlet VSD that spontaneously closed by formation of aneurysm of the membranous septum is reported.
M Papa; F Santoro; A Corno
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  104     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-02     Completed Date:  1993-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  620-2     Citation Subset:  AIM; IM    
Department of Cardiology, Istituto Scientifico San Raffaele, University of Milan, Italy.
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MeSH Terms
Abnormalities, Multiple*
Aortic Coarctation / complications*
Down Syndrome / complications*
Ductus Arteriosus, Patent / complications
Heart Septal Defects, Ventricular / complications*,  pathology,  ultrasonography
Remission, Spontaneous

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