Document Detail

Spontaneous baroreflex sensitivity in young and older people during voluntary and electrically evoked isometric exercise.
MedLine Citation:
PMID:  12242198     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In young people, cardiovagal baroreflex sensitivity alters during isometric exercise. We investigated whether the reduced resting baroreflex sensitivity seen with increasing age is similarly altered during exercise. METHODS: Cardiovagal baroreflex sensitivity was examined in 8 young (age+/-SEM, 25+/-1.7 years) and 9 older (61+/-3.0 years) subjects, using sequence analysis during voluntary and electrically evoked isometric exercise (at 30% maximum voluntary strength) and during subsequent post-exercise circulatory occlusion. RESULTS: In all phases of both conditions, baroreflex sensitivity was significantly reduced in the older group compared with the young group. (Median (interquartile range), voluntary 7.0 (4.4) vs 3.6 (3.8) ms x mmHg(-1), post-exercise circulatory occlusion 9.0 (8.2) vs 4.6 (4.0) ms x mmHg(-1); electrically evoked 6.6 (10.6) vs 3.2 (3.6) ms x mmHg(-1), post-exercise circulatory occlusion 8.3 (7.7) vs 2.9 (2.2) ms x mmHg(-1), young vs older respectively; P<0.05.) There was a marked rightward shift (resetting) of the baroreflex during exercise with the exception of electrically evoked in the older group. CONCLUSION: Our data demonstrate that the reduction in baroreflex sensitivity in older people is maintained during exercise and during post-exercise circulatory occlusion. Resetting of the baroreflex in the older subjects during moderate voluntary isometric calf exercise is largely the result of central command.
Charlotte A Carrington; Michael J White
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Age and ageing     Volume:  31     ISSN:  1468-2834     ISO Abbreviation:  Age Ageing     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-20     Completed Date:  2008-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375655     Medline TA:  Age Ageing     Country:  England    
Other Details:
Languages:  eng     Pagination:  359-64     Citation Subset:  IM    
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
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MeSH Terms
Aging / physiology*
Baroreflex / physiology*
Blood Pressure / physiology
Electric Stimulation
Exercise / physiology*
Heart Rate / physiology
Middle Aged
Muscle, Skeletal / innervation
Neurons, Afferent / physiology
Regression Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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